Terbium sensitized luminescence for the determination of fexofenadine in pharmaceutical formulations

Abstract

A sensitive and specific luminescence method for the determination of Fexofenadine (FEX), in pharmaceutical formulations is reported. The method is based on the sensitization of terbium (Tb 3+ ) by complex formation with FEX. The luminescence signal for Tb-FEX complex is greatly enhanced by the addition of triethylamine (ET 3 N) and zinc nitrate in methanol solution.Monitoring of the signal is accomplished when the instrument is in the phosphorescence mode with the excitation and emission wavelengths set at k ex = 220 nm and k em = 550 nm respectively. Optimum conditions for the formation of the complex in methanol were 2.25 · 10 À6 M of Tb 3+ , 5.00 · 10 À6 M of Et 3 N and Zn 2+ which allows for the determination of 10-800 ppb of FEX in the batch mode with a detection limit of 0.3 ppb. The proposed method was successfully applied for the determination of FEX in pharmaceutical formulations. ª 2015 The Authors. Production and hosting by Elsevier B.V. on behalf of King Saud University. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

Analytical Methods for Determination of Salbutamol, Ambroxol and Fexofenadine

“…Ideal conditions for the arrangement of the complex in methanol were 2.25 × 10−6 M of Tb3+, 5.00 × 10−6 M of Et3N and Zn2+ which takes into consideration the assurance of 10-800 ppb of FEX in the clump mode with a recognition cutoff of 0.3 ppb. The proposed strategy was effectively applied for the assurance of FEX in pharmaceutical plans [88].…”

Application of Samarium- and Terbium-Sensitized Luminescence via a Multivariate-Based Approach for the Determination of Orbifloxacin

“…Possessing unique luminescent characteristics when complexed with organic ligands (recognized as the antennas), lanthanide-sensitized luminescence has been recently widely described for the detection of drugs and pharmaceuticals [19][20][21][22][23][24]. Among these characteristics, the unique decay times allow an effective distinction between the background interferences in analyses.…”

“…Following the complexation, energy is transferred to the triplet state of the molecule and then to the core lanthanide ion resonance level, enhancing its luminescence intensity. Finally, radiation is emitted at the characteristic wavelength of the lanthanide ion [19][20][21][22][23][24][25][26][27].…”

Green Spectrofluorimetric Technique for the Determination of Vildagliptin Through Quenching Lanthanide Luminescence in Pure, Pharmaceutical Dosage Form and Spiked Plasma

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