Terbutaline Prevents Circulatory Failure and Mitigates Mortality in Rodents With Endotoxemia

Salmeterol, a β2-receptor agonist, attenuates lipopolysaccharide-induced lung inflammation in mice

“…Previously, other ␤ 2 -receptor agonists have been studied in inflammatory models and found to be effective in attenuating neutrophil influx. In a model of carrageenin-induced pleurisy in mice, salbutamol strongly inhibited neutrophil migration (29), whereas in a rat model of endotoxemia both liver and lung showed only minimal neutrophil influx in animals treated with terbutaline 30 min before LPS challenge (46). These data show that different ␤ 2 -receptor agonists are able to interfere with neutrophil migration in vivo.…”

“…Earlier studies have documented the anti-inflammatory effects of ␤-receptor stimulation on the cytokine network. Indeed, ␤-receptor agonists potently inhibited the production of TNF-␣ by monocytes in vitro and in mice and normal humans in vivo (5,32,33,38,42,46). In addition, ␤-receptor stimulation resulted in an enhanced release of the anti-inflammatory cytokine IL-10 in these models (36,38,42,46).…”

Acute phase response impairs host defense against Pseudomonas aeruginosa pneumonia in mice*

“…We next wished to determine a possible role of ␤-adrenergic activation in the effect of the acute phase response on neutrophil recruitment and host defense during pneumonia considering that a) ␤-adrenergic agonists diminished neutrophil recruitment to the lungs of experimental animals (23,33,34); b) ␤-receptor stimulation resulted in a reduced CD11b expression on blood neutrophils in mice in vivo (23); and c) catecholamines played a major role in the impaired host defense against pneumonia after stroke (24). To determine the role of the ␤-adrenergic activation in our model, we treated mice with either propranolol, a ␤-adrenergic receptor antagonist, or vehicle.…”

Acute Stress Elicited by Bungee Jumping Suppresses Human Innate Immunity

“…We specifically investigated the effects of catecholamines, since these hormones are universally released during stress and β-adrenergic stimulation has been shown to dramatically influence cytokine secretion in a variety of in vitro and in vivo models (5,7,25,26). In these studies, both exogenously administered and endogenously released catecholamines were reported to decrease TNF-α secretion in humans and mice challenged with LPS in vivo (7,25,26), whereas the ability of epinephrine to enhance the release of IL-10 has been demonstrated in a human study in which this catecholamine was intravenously infused (5). In this study, bungee jumping was associated with an immune suppressive phenotype, since we observed a reduction in the release of the proinflammatory mediators TNF-α and IL-8 in whole blood stimulated with LPS as well as a reduction in the ability of leukocytes to phagocytose bacteria after jumping.…”