2023
DOI: 10.24425/pjvs.2023.148279
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Teriflunomide induces Foxp3 expression in murine CD8 + T cells while IL-27 and retinoic acid exert a synergistic effect on the induction of CD39 expression on these cells

T. Maślanka,
A. Jasiecka-Mikołajczyk

Abstract: The purpose of this study was to verify the possibility of pharmacological induction of Foxp3 + CD25 + CD8 + and Foxp3 -CD103 + CD8 + T regulatory cells 'armed' with immunosuppressive molecules, i.e. CD39 and IL-10. To achieve this purpose, stimulated and unstimulated murine lymphocytes were exposed to IL-27, teriflunomide (TER) and all trans retinoic acid (ATRA). The study found that: (a) IL-27 induced CD39 expression on Foxp3 + CD25 + CD8 + T cells and the ability of CD103 + Foxp3 -CD8 + T cells to produce I… Show more

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