Teriparatide in the Treatment of a Loose Hip Prosthesis

Zati, A.; Sarti, D.; Malaguti, Maria Cristina; Pratelli, Loredana

doi:10.3899/jrheum.100980

Cited by 18 publications

(15 citation statements)

References 9 publications

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“…It was reported that daily injection with TPTD (40 mg/kg/day) for 7 weeks significantly enhanced femoral bone strength, which was associated with improvement of femoral BMD, bone markers, and bone structure (18). In addition, several clinical case reports found that patients diagnosed with prosthetic aseptic loosening experience clinical improvement with disappearance of radiographic signs of loosening after 6-8 months TPTD treatment, indicating that TPTD may be a potential new alternative treatment for the prevention of particle-induced periprosthetic osteolysis and sequential aseptic loosening (47,48). However, results of the present study indicated that 2 weeks of TPTD treatment could not inhibit the Ti particle-induced bone resorption in OVX and Sham-OVX mice as effective as ZOL, which was contradictory with our hypothesis.…”

Section: Prevention Of Titanium Particle-induced Calvarial Osteolysismentioning

confidence: 98%

Antiresorptive Agents are More Effective in Preventing Titanium Particle‐Induced Calvarial Osteolysis in Ovariectomized Mice Than Anabolic Agents in Short‐Term Administration

Ouyang

et al. 2018

Artificial Organs

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Aseptic loosening due to wear particle‐induced osteolysis is the main cause of arthroplasty failure and the influence of postmenopausal osteoporosis and anti‐osteoporosis treatment on Titanium (Ti) particle‐induced osteolysis remains unclear. 66 C57BL/6J female mice were used in this study. Ovariectomy (OVX) was performed to induce osteopenia mice and confirmed by micro‐CT. The Ti particle‐induced mouse calvaria osteolysis model was established subsequently and both OVX and Sham‐OVX mice were divided into four groups, respectively: Ti (‐) group, Ti group, Ti + zoledronic acid (ZOL) group (50ug/kg, local administration, single dose) and Ti + teriparatide (TPTD) group (40ug/kg/d, subcutaneous injection*14d). Mice calvarias were collected for micro‐CT and histomorphometric analysis 2 weeks after particle induction. 8 weeks after bilateral OVX, significantly reduced BMD and microstructure parameters in both proximal tibia and calvaria were observed in OVX mice when comparing with Sham‐OVX mice. OVX mice in Ti group had not only markly decreased BMD and BV/TV, but also significantly increased total porosity, eroded surface area and osteoclast numbers when comparing with Sham‐OVX mice. Shown by Two‐way ANOVA analysis, the interaction terms between OVX and Ti implantation on micro‐CT and histomorphometry parameters didn’t reach significant difference. As illustrated by micro‐CT and histological analysis, ZOL treatment markedly inhibited Ti particle‐induced osteolysis in OVX mice and Sham‐OVX mice, and there were significant differences when comparing to both Ti and Ti+TPTD group. The combination of osteoporosis and Ti particle implantation result in aggravated bone resorption, accompanied with increased osteoclasts and excessive inflammation response. ZOL was more effective in preventing Ti particle‐induced osteolysis in both OVX mice and Sham‐OVX mice than TPTD in short‐term administration. ZOL exert the protective effects on Ti particle‐induced bone loss via the suppression of osteoclasts.

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Section: Prevention Of Titanium Particle-induced Calvarial Osteolysismentioning

confidence: 98%

Antiresorptive Agents are More Effective in Preventing Titanium Particle‐Induced Calvarial Osteolysis in Ovariectomized Mice Than Anabolic Agents in Short‐Term Administration

Ouyang

et al. 2018

Artificial Organs

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“…In vivo, PTH has been found to increase bone formation and strength around screws and can increase the pull-out force [66]. PTH is beginning to be used for the treatment of aseptic loosening [67,68]. Sclerostin antibody is associated with a larger anabolic window, which may result in greater increases in bone formation in the short term than with agents such as PTH.…”

Section: Discussionmentioning

confidence: 98%

Sclerostin monoclonal antibodies on bone metabolism and fracture healing

Gamie

Korres

Leonidou

et al. 2012

Expert Opinion on Investigational Drugs

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“…While this conversion has not been examined in the context of particle‐induced osteolysis, there is one experiment in which a formerly loose implant was stabilized via the use of a hydroxyapatite coating . To our knowledge, the possibility of rescuing a loose implant with an anabolic agent has not been examined in an animal model, although intermittent PTH treatment has been reported in two clinical case studies to improve implant fixation …”

Section: Discussionmentioning

confidence: 99%

“…114 To our knowledge, the possibility of rescuing a loose implant with an anabolic agent has not been examined in an animal model, although intermittent PTH treatment has been reported in two clinical case studies to improve implant fixation. 115,116 Other areas of research that could use more study include the role of the synovium and discovery of biomarkers. Willert and Semlitsch explicitly stressed the importance of the joint capsule and synovium in osteolysis 40 years ago.…”

Section: Discussionmentioning

confidence: 99%

Arthrotomy‐based preclinical models of particle‐induced osteolysis: A systematic review

Moran

Wilson

Ross

et al. 2017

Journal Orthopaedic Research

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We completed a systematic literature review of in vivo animal models that use arthrotomy-based methods to study particle-induced peri-implant osteolysis. The purpose of the review was to characterize the models developed to date, to determine the questions addressed, to assess scientific rigor and transparency and to identify gaps in knowledge. We probed three literature databases (Medline, Embase and Scopus) and found 77 manuscripts that fit the search parameters. In the most recent 10 years, researchers mainly used rat and mouse models, whereas in the previous 20 years large animal, canine and rabbit models were more common. The studies have demonstrated several pathophysiology pathways, including macrophage migration, particle phagocytosis, increased local production of cytokines and lysosomal enzymes, elevated bone resorption and suppressed bone formation. The effect of variation in particle characteristics and concentration received limited attention with somewhat mixed findings. Particle contamination by endotoxin was shown to exacerbate peri-implant osteolysis. The possibility of early diagnosis was demonstrated through imaging and biomarker approaches. Several studies showed that both local and systemic delivery of bisphosphonates inhibits the development of particle-induced osteolysis. Other methods of inhibiting osteolysis include the use of anabolic agents and altering the implant design. Few studies examined non-surgical rescue of loosened implants, with conflicting results with alendronate. We found that the manuscripts often lacked the methodological detail now advocated by the ARRIVE guidelines, suggesting that improvement in reporting would be useful to maximize rigor and transparency.

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Teriparatide in the Treatment of a Loose Hip Prosthesis

Cited by 18 publications

References 9 publications

Antiresorptive Agents are More Effective in Preventing Titanium Particle‐Induced Calvarial Osteolysis in Ovariectomized Mice Than Anabolic Agents in Short‐Term Administration

Antiresorptive Agents are More Effective in Preventing Titanium Particle‐Induced Calvarial Osteolysis in Ovariectomized Mice Than Anabolic Agents in Short‐Term Administration

Sclerostin monoclonal antibodies on bone metabolism and fracture healing

Arthrotomy‐based preclinical models of particle‐induced osteolysis: A systematic review

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