Terlipressin as rescue treatment of refractory shock in a neonate

Abstract

Terlipressin appears an effective rescue treatment in patients with refractory vasodilatory septic shock. Further studies are required to assess its efficacy and safety in neonatal population.

Vasopressin improves systemic hemodynamics without compromising mesenteric perfusion in the resuscitation of asphyxiated newborn piglets: a dose–response study

“…Currently, the use of vasopressin or terlipressin has focused on rescuing newborns with hypotension refractory to standard catecholamines [6][7][8][9][10][11]. A small number of case reports of infant resuscitation with vasopressin or terlipressin have shown prompt reversal of hypotension and improved tissue perfusion, without adverse affects [7][8][9][10][11].…”

“…Despite widespread use of vasopressin and its synthetic analogue terlipressin for hypotensive shock in adults [4,5], vasopressin use remains limited in the neonatal population. Case reports and observational studies in neonates, using vasopressin or terlipressin, have suggested a beneficial effect; however, effective dosing, systemic hemodynamics, and local effects upon target organs remain unexplored [6][7][8][9][10][11]. Our objective was to assess the dose-response effects of vasopressin on systemic hemodynamics, along with mesenteric and cerebral perfusion in asphyxiated newborn piglets.…”

Terlipressin as rescue therapy for refractory pulmonary hypertension in a neonate with a congenital diaphragmatic hernia

“…Terlipressin was effective in children with hypotension in catecholamine resistant septic shock [11]. In neonates, terlipressin [12] was reported to correct hypotension in vasodilatory shock. Recently, Papoff et al [13] described a similar case of congenital diaphragmatic hernia and PPH managed with terlipressin.…”

Congenital Plasmodium vivax malaria mimicking neonatal sepsis: a case report

“…In endemic countries congenital malaria is mainly caused by P. falciparum [4]. In European countries most cases are due to Plasmodium malariae and P. vivax [5], associated with the decrease over time of malaria immunity, and the immunosuppression observed at the end of pregnancy [5]. …”