The Complement System
DOI: 10.1007/1-4020-8056-5_6
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Terminal Complement Complex: Regulation of Formation and Pathophysiological Functions

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Cited by 16 publications
(21 citation statements)
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“…Moreover, complement components are readily available as a first line of defense against cancer cells because they are locally synthesized by many cell types, including macrophages (20), fibroblasts (21), and endothelial cells (22,23). However, a major limitation of complement as an effector system against tumor cells is represented by the complement-regulatory proteins expressed on the cell surface (mCRPs; refs.…”
Section: Introductionmentioning
confidence: 99%
“…Moreover, complement components are readily available as a first line of defense against cancer cells because they are locally synthesized by many cell types, including macrophages (20), fibroblasts (21), and endothelial cells (22,23). However, a major limitation of complement as an effector system against tumor cells is represented by the complement-regulatory proteins expressed on the cell surface (mCRPs; refs.…”
Section: Introductionmentioning
confidence: 99%
“…The complement system has a definite advantage over cytotoxic cells as a defense system because it is made up of soluble molecules that can easily reach the tumor site and diffuse inside the tumor mass. Moreover, complement components are readily available as a first line of defense because they are synthesized locally by many cell types, including macrophages [4] fibroblasts [5] and endothelial cells [6].…”
Section: Introductionmentioning
confidence: 99%
“…Most importantly, these structures allowed identification of Arg 44 Complement is a primary arm of innate immunity that plays essential roles in clearance of microbial invaders and immune complexes, initiation of inflammation, development, and differentiation and serves as a bridge to the adaptive immune response (1). Activation of complement may be achieved spontaneously and continuously (tick-over) or via binding of pattern recognition proteins to pathogen-specific surface structures to trigger either the classical, lectin, or alternative pathways (AP).…”
mentioning
confidence: 99%