1996
DOI: 10.1128/mcb.16.7.3285
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Terminal Long Tandem Repeats in Chromosomes from Chironomus pallidivittatus

Abstract: We provide evidence that a chromosome end in the dipteran Chironomus pallidivittatus contains 340-bp tandem repeats reaching the extreme terminus of the chromosome. After adding synthetic oligonucleotide tails to DNA extracted from the microdissected right end of the fourth chromosome, we could demonstrate that the blocks of repeats were tailed at only one end, the chromosome terminus, the interior of the arrays being unavailable for tailing. Using PCR, we furthermore showed that the added tails were connected… Show more

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Cited by 62 publications
(65 citation statements)
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“…Species that had no cross-hybridization included the five Diptera and three of the eight Coleoptera studied. Lack of cross-hybridization does not prove that a species lacks telomerase; however, at least two Diptera, D. melanogaster and Chironomous pallidivittatus, are known to have chromosome end sequences that differ significantly from the simple repeats generated by telomerase (2,23,24). Thus these species have either lost telomerase or, as we have argued (3,25), their telomerase has undergone significant evolution.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…Species that had no cross-hybridization included the five Diptera and three of the eight Coleoptera studied. Lack of cross-hybridization does not prove that a species lacks telomerase; however, at least two Diptera, D. melanogaster and Chironomous pallidivittatus, are known to have chromosome end sequences that differ significantly from the simple repeats generated by telomerase (2,23,24). Thus these species have either lost telomerase or, as we have argued (3,25), their telomerase has undergone significant evolution.…”
Section: Discussionmentioning
confidence: 99%
“…Telomeres in D. melanogaster are composed of the retrotranposons, HeT-A and TART, whereas telomeres in C. pallidivittatus and Chironomous thummi are composed of large complex repeats (23,24). The mechanism by which the Chironomous repeats are generated is not known.…”
Section: Discussionmentioning
confidence: 99%
“…1C), suggesting that telomere elongation takes place by homologous recombination. 21 In Drosophila, however, telomeres are primarily maintained by transposition of telomeric retrotransposons to receding chromosome ends (Fig. 1D), and, as in any eukaryote, by recombination (reviewed in refs.…”
Section: Introductionmentioning
confidence: 99%
“…Both telomerase and transposition contribute to telomere maintenance in the green alga Chlorella (17). Telomere-telomere recombination is thought to be the sole mechanism for maintaining the repeats at chromosome ends in some insects, such as the mosquito Anopheles (40) and the dipteran Chironomus (23).…”
mentioning
confidence: 99%