The traditional procedure of predicting the settling velocity of a spherical particle is inconvenient as it involves iterations, complex correlations, and an unpredictable degree of uncertainty. The limitations can be addressed efficiently with artificial intelligence-based machine-learning algorithms (MLAs). The limited number of isolated studies conducted to date were constricted to specific fluid rheology, a particular MLA, and insufficient data. In the current study, the generalized application of ML was comprehensively investigated for Newtonian and three varieties of non-Newtonian fluids such as Power-law, Bingham, and Herschel Bulkley. A diverse set of nine MLAs were trained and tested using a large dataset of 967 samples. The ranges of generalized particle Reynolds number (ReG) and drag coefficient (CD) for the dataset were 10−3 < ReG (-) < 104 and 10−1 < CD (-) < 105, respectively. The performances of the models were statistically evaluated using an evaluation metric of the coefficient-of-determination (R2), root-mean-square-error (RMSE), mean-squared-error (MSE), and mean-absolute-error (MAE). The support vector regression with polynomial kernel demonstrated the optimum performance with R2 = 0.92, RMSE = 0.066, MSE = 0.0044, and MAE = 0.044. Its generalization capability was validated using the ten-fold-cross-validation technique, leave-one-feature-out experiment, and leave-one-data-set-out validation. The outcome of the current investigation was a generalized approach to modeling the settling velocity.