Terminal Warm Blood Cardioplegia Improves Cardiac Function Through Microtubule Repolymerization

Tenpaku, Hironori; Onoda, Koji; Imanaka‐Yoshida, Kyoko; Yoshida, Toshimichi; Shimono, Takatsugu; Shimpo, Hideto; Yada, Isao

doi:10.1016/s0003-4975(98)00237-9

Cited by 4 publications

(8 citation statements)

References 22 publications

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“…Other authors have also reported tubulin repolymerization on cardiac myocytes 10 and isolated rat hearts. 47 The discordance between the results of Calaghan et al 20 obtained under two variations of the patch-clamp technique is unexpected. The strength of their argument is, however, weakened first by the technical difficulties related to the large series resistance in the perforated mode and, more importantly, by the maze of steps required to measure I Ca in rat ventricular myocytes without effectively blocking K ϩ currents.…”

Section: Discussionmentioning

confidence: 94%

Microtubule Disruption by Colchicine Reversibly Enhances Calcium Signaling in Intact Rat Cardiac Myocytes

Kerfant

Vassort

Gómez

2001

Circulation Research

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Abstract-Using the whole-cell patch-clamp configuration in rat ventricular myocytes, we recently reported that microtubule disruption increases calcium current (I Ca ) and [Ca 2ϩ ] i transient and accelerates their kinetics by adenylyl cyclase activation. In the present report, we further analyzed the effects of microtubule disruption by 1 mol/L colchicine on Ca 2ϩ signaling in cardiac myocytes with intact sarcolemma. In quiescent intact cells, it is possible to investigate ryanodine receptor (RyR)

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Section: Discussionmentioning

confidence: 94%

Microtubule Disruption by Colchicine Reversibly Enhances Calcium Signaling in Intact Rat Cardiac Myocytes

Kerfant

Vassort

Gómez

2001

Circulation Research

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“…They include better preservation of high-energy phosphates and endogenous amino acids, less anerobic metabolic activity on reperfusion, reduced release of cardiac troponin T, and improved post-ischemic functional recovery. 3,4,6 –8 These effects facilitate coronary vasodilatation and accelerate early myocardial tissue oxygen saturation during warm reperfusion. 4,6 Tenpaku and colleagues 7 demonstrated complete microtubule repolymerization after 10 min of reperfusion with warm blood.…”

Section: Discussionmentioning

confidence: 99%

Terminal Warm Blood Cardioplegia in Mitral Valve Replacement: Prospective Study

Rergkliang

Chetpaophan

Chittithavorn

et al. 2006

Asian Cardiovasc Thorac Ann

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Terminal warm blood cardioplegia has had a profound impact on cardiac surgery, especially in coronary artery bypass surgery, but there have been few studies on its use in mitral valve replacement. The purpose of this study was to determine whether terminal warm blood cardioplegia offers any advantages in mitral valve replacement. Forty patients with mitral valve disease were prospectively randomized to one of two groups of 20 with different techniques of myocardial protection: group A had cold blood cardioplegia, and group B had cold blood cardioplegia with terminal warm blood cardioplegia. Intraoperative and postoperative variables were used to assess primary outcomes. Postoperative troponin T release was measured as a secondary outcome. Improved spontaneous recovery of sinus rhythm was observed in group B, but the difference was not significant. The maximum doses of inotropics, duration of inotropic support, intensive care unit stay, and postoperative left ventricular ejection fraction were similar in both groups. Troponin T release at 0 and 6 h postoperatively was not different between the two groups. This study did not find any benefit of terminal warm blood cardioplegia in either clinical outcome or troponin T release after mitral valve replacement.

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“…Since many years we changed the cardioplegia solution from crystalloid into blood, based on western clinics guidelines and conditions of our clinic. Since 2008 we use successfully warm blood cardioplegia (Calafiore cardioplegia protocol) [1] and, with very good results [4,5] Blood cardioplegia has had a profound impact on cardiac surgery, especially in coronary artery bypass surgery [4] Warm blood cardioplegia is used to modify reperfusion injury, resulting in improved postoperative contractile function and decreased mortality [3,4,6,7,8] . Very safe predictors of good myocardial protection are BNP [9,10,11,12], TnI [12,13,14] and Lactic Acid [15,16] measured before and after Cardiopulmonary Bypass (CPB).…”

Section: Introductionmentioning

confidence: 99%

BNP, TnI and Lactic Acid variations in Warm Blood Cardioplegia vs Cold Crystalloid Cardioplegia in Coronary Artery Bypass Grafting (CABG)

2022

ALST

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Introduction: Myocardial protection is one of the key points during cardiac surgery. Inadequate myocardial protection in cross-clamping period is an issue of concern in cardiac surgery. Cardioplegic solutions improve the tolerance of ischemia and reperfusion by preserving myocardial energy reserves, preventing osmotic, electrolyte imbalances and acidosis. Warm blood cardioplegia (WBC) has had a profound impact, especially in coronary artery bypass surgery and there have been many studies that compared it with Cold crystalloid cardioplegia (CCC). A good myocardial protection will be reflected especially on patients outcome, on postoperative ICU strategy, morbidity and mortality as well. Brain Natriuretic Peptide (BNP), Troponin I (TnI) and Lactic Acid LA) are very significant biomarkers that reflects an adequate myocardial and organ perfusion/protection. The purpose of this study is to determine if warm blood cardioplegia offers any advantages in comparison with CCC in Coronary Artery Bypass Grafting (CABG) based primary on variations of BNP, TnI and Lactic Acid. Patients and method: 60 patients with coronary artery disease (CAD) that will have Coronary Artery Bypass Surgery (CABG), were retrospectively randomized in two groups of 30 patients with different techniques of myocardial protection: group A had CCC, and group B had warm blood cardioplegia (WBC), according to Calafiore [1] protocols). Intraoperative and postoperative variables were used to assess primary outcomes. Results: This study found benefits of warm blood cardioplegia in clinical outcome after CABG

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Terminal Warm Blood Cardioplegia Improves Cardiac Function Through Microtubule Repolymerization

Cited by 4 publications

References 22 publications

Microtubule Disruption by Colchicine Reversibly Enhances Calcium Signaling in Intact Rat Cardiac Myocytes

Microtubule Disruption by Colchicine Reversibly Enhances Calcium Signaling in Intact Rat Cardiac Myocytes

Terminal Warm Blood Cardioplegia in Mitral Valve Replacement: Prospective Study

BNP, TnI and Lactic Acid variations in Warm Blood Cardioplegia vs Cold Crystalloid Cardioplegia in Coronary Artery Bypass Grafting (CABG)

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