BACKGROUND:The aging Taiwan population is expected to require vast medical resources, including prolonged mechanical ventilation (PMV). This study determined the trends in hospital resource utilization and associated factors in PMV patients in Taiwan . During the study period, stay significantly decreased, from 35.12 days to 31.61 days, whereas hospital treatment costs significantly increased, from $7,933.17 to $8,257.52 (P < .001). Considerably decreased stay and increased hospital treatment costs were significantly associated with age, number of comorbidities, hospital level, hospital volume, and patient referral source (P < .001). CONCLUSIONS: These population-based data demonstrated a decrease in the prevalence of PMV, especially for older patients, and that stay decreased; however, hospital treatment costs increased. Moreover, healthcare providers and patients should recognize that attributes of both the patient and the hospital may affect hospital resource utilization. Additionally, these analytical results should be applicable to similar populations in other countries.