Terminalia arjuna Extract Attenuates Isoproterenol-Induced Cardiac Stress in Wistar Rats via an Anti-Apoptotic Pathway

Thangaraju, Mohan Manu; Anand, T.; Bhat, Pratiksha V.; Deshetty, Uma Maheswari; Babusha, Sudalaimuthu Thangaraj; Khanum, Farhath

doi:10.1007/s40011-020-01180-4

Cited by 7 publications

(3 citation statements)

References 38 publications

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“…By reducing the levels of free radicals it shows its anti-apoptotic properties such as ROS (Reactive Oxygen Species), hydroperoxide, and nitrite, as well as the rate of lipid peroxidation. It also increased antioxidant enzymes (superoxide dismutase, glutathione reductase, catalase, and glutathione peroxidase) and total glutathione levels 34 . It exhibits its anti-atherogenic properties by increasing adiponectin while lowering pro-inflammatory adipokines and leptin levels 35 .…”

Section: Treatmentmentioning

confidence: 92%

“Perspective of Ischemic Heart Disease (Iqfari Marad-i-Qalb) with reference to Unani Medicine”

Eram,

Quamri,

Ahmad Bhat

et al. 2023

Bangladesh J Med Sci

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Background: Ischemic heart disease (IHD) also known as coronary artery disease (CAD) is the leading cause of death worldwide. IHD is caused by obstruction of one or more coronary arteries. Among the various causes of obstruction atherosclerosis is the leading cause. Physical inactivity, smoking, saturated fat rich diet, hypertension, diabetes mellitus, dyslipidaemia are modifiable risk factors for atherosclerosis which ultimately results in IHD. In this article we will discuss the disease in the light of Unani system of Medicine and how to manage it depending on the understood concepts Methods: A number of classical Unani textbooks were referred for description of various heart diseases and various search engines such as PubMed, Google Scholar and Research Gate were cited for recent advancements using the key words IHD, atherosclerosis, cardio-protective herbal drugs, etc. Conclusion: Owing to the irreversible damage due to IHD it is better to prevent myocardium damage by minimising the risk factors at its earliest. In Unani system of medicine many cardio-protective drugs have been described which when combined with lifestyle modification can play vital role in keeping cardiac diseases at bay. Bangladesh Journal of Medical Science Vol. 22 No. 03 July’23 Page : 475-481

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Section: Treatmentmentioning

confidence: 92%

“Perspective of Ischemic Heart Disease (Iqfari Marad-i-Qalb) with reference to Unani Medicine”

Eram,

Quamri,

Ahmad Bhat

et al. 2023

Bangladesh J Med Sci

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“…It is known by its various vernacular names, the most commonly used ones are Arjuna (Common Name), Arjun (Hindi), Marudhu (Tamil and Malayalam), Tella Maddi (Telugu), Arjhan (Bengali), Sadaru (Marathi), Sadado (Gujarati), Neer matti (Kannada). 2,3 © 2023 the authors. This work is licensed under the Creative Commons Attribution 4.0 International License of morphology, functional capacity, growth, development, or life span of the target organism under defined conditions of exposure of T. arjuna bark hydro-alcoholic extract i.e., No-Observed-Adverse-effect Level (NOAEL)and target organs of toxicity, if any.…”

Section: Introductionmentioning

confidence: 99%

Acute and Sub-Acute Oral Toxicity Studies of Hydroalcoholic Extract of Terminalia arjuna (Roxb.) Bark in Rodents

2023

TJNPR

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T. arjuna bark contains various triterpenoids, glycosides, flavonoids, phenolics, tannin, minerals, and trace elements. Triterpenoids include arjunin, arjunic acid, arjunenin, terminic acid, terminoltin, and arjunolic acid. Glycosides includes, arjunetin, arjunoside I, II, arjunolone, arjunolitin arjunaphthanoloside, arjunglucoside IV and V, arjunasides a-e, olean-3b, 22b-diol-12-en-28 b-d-glucopyranosie-oic acid, terminarjunoside I and II, terminoside a and termionic acid. Flavonoids and phenolics includes, arjunone, luteolin, baicalein, ethyl gallate, gallic acid, kempferol, oligomeric, proanthocyanidins, pelargonidin, quercetin, (þ)-catechin, (þ)-gallocatechin and (-)-epigallocatechin, ellagic acid and its derivatives such as 3-O-methyl-ellagic acid 4-O-bdxylopyranoside, 3-O-methyl ellagic acid 3-O-rhamnoside, 3-O-methyl ellagic acid 40-O-a-L-rhamnophranoside, (-)-epicatechin. Tannins include, pyrocatechols, punicallin, castalagin, casuariin, casuarinin, punicalagin, terchebulin, and terflavin C. Minerals and trace elements includes, calcium, magnesium, aluminum, zinc, copper, silica. 4 It has been reported that T.arjuna possesses multiple medicinal properties, such as antioxidant, antidiabetic, antimicrobial, cardioprotective, antiarthritic, antidiarrheal, anti-dysenteric, CVS and CNS stimulator, diuretic in cirrhosis of liver and strangury, abortifacient, and analgesic activity. It also has been reported to decrease the level of serum triglycerides and cholesterol, recover the level of high-density lipoproteins, act as an anti-ischemic agent, relieve myocardial necrosis, modulate platelet aggregation and act as an effective antioxidant. Ayurveda pharmacopeia of India recommends the powder of the stem bark in emaciation, chest diseases, lipid imbalances and polyuria, hypercholesterolemia, as well as in fungal and microbial infections, or as anti-fertility and antidote against poisons. Terminalia arjuna, traditionally has been used as a cardiotonic and cardioprotective, and has been designated for instability of three humours viz., vata, pitta and kapha as per Ayurveda. [5][6][7][8][9] T.arjuna bark is used widely by herbal medicine practitioners for treating cardiovascular diseases. Few clinical trials and preclinical studies have already been reported, however, there are no kinds of literature available on repeated dose toxicology studies conducted in rats for the bark of T.arjuna. Hence, this study was designed to find out the greatest concentration, that causes no detectable adverse alteration

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“…The scavenging of free radicals produced by Isoproterenol-induced stress is thought to be the mechanism of Terminalia arjuna extract cardioprotection. Cardioprotective and antioxidant properties of Terminalia arjuna extract could be seen through its ability to reduce heart damage induced by ISO, involving oxidative stress and apoptosis 24 . In this study, T. arjuna rendered cardiac protection by scavenging the free radicals generated by ISO.…”

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confidence: 99%

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2023

IJPSR

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The objective of this study is to investigate the protective effect of aqueous bark extract of Terminalia arjuna (TA) on high-fat dietinduced cardiovascular changes in Wistar rats using histological, immunohistochemical, and gene expression analysis. Group 1-without treatment served as control, group 2-High fat diet (HFD) received corn oil orally at a dose of 10 mL/kg, group 3 -HFD+atorvastatin (ATV) -10 mg/kg, group 4 -HFD+TA125 mg/kg , and group 5-HFD+TA250 mg/kg, 6 days a week for 5 weeks. The activity of MMP-9 was measured in blood, Hematoxylin and Eosin staining was analyzed with heart tissue and TNF-α immunohistochemistry and ADIPOQ gene expression analysis were conducted using heart tissue. When Compared to the control group, the HFD group showed higher levels of MMP-9 activity and morphological changes in heart histology. TNF-α expression was also significantly increased in HFD group and down-regulation of ADIPOQ gene expression levels. MMP-9 activity and pathological damage to cardiac tissue including ADIPOQ gene expression were significantly reverted when T. arjuna bark extract was administered along with a high-fat diet. The findings reveal that T. arjuna bark has protective against HFD-induced cardiovascular alterations. INTRODUCTION:Heart disease remains the predominant cause of mortality in the United States as well as worldwide. Even in European nations, cardiovascular disease (CVD) and stroke continue QUICK RESPONSE CODE

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Terminalia arjuna Extract Attenuates Isoproterenol-Induced Cardiac Stress in Wistar Rats via an Anti-Apoptotic Pathway

Cited by 7 publications

References 38 publications

“Perspective of Ischemic Heart Disease (Iqfari Marad-i-Qalb) with reference to Unani Medicine”

“Perspective of Ischemic Heart Disease (Iqfari Marad-i-Qalb) with reference to Unani Medicine”

Acute and Sub-Acute Oral Toxicity Studies of Hydroalcoholic Extract of Terminalia arjuna (Roxb.) Bark in Rodents

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