Terminalia Arjuna (Roxb.) Modulates Circulatory Antioxidants on 7,12-dimethylbenz(a)anthracene- induced Hamster Buccal Pouch Carcinogenesis

Dhanarasu, Sasikumar

doi:10.5001/omj.2010.81

Cited by 5 publications

(4 citation statements)

References 29 publications

(23 reference statements)

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“…Measurement of plasma lipid peroxidation by-products helps to assess the extent of tissue damage. Extensive studies suggested that lipid peroxides that are generated excessively at the primary site could be transferred through circulation to other organs and provoke damage by propagating lipid peroxidation (Dhanarasu et al, 2010). Increased plasma TBARS observed in the plasma of hamsters treated with DMBA alone is probably due to over production and diffusion of lipid peroxidation by-products from the damaged host tissues with subsequent leakage into plasma (Senthil et al, 2007).…”

Section: Discussionmentioning

confidence: 99%

Saffron Reduction of 7,12-Dimethylbenz[a]anthracene-induced Hamster Buccal Pouch Carcinogenesis

Manoharan

Wani²,

Vasudevan³

et al. 2013

Asian Pacific Journal of Cancer Prevention

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Our aim was to investigate the chemopreventive potential of saffron in DMBA-induced hamster buccal pouch carcinogenesis. Assessment was by monitoring the percentage of tumor bearing hamsters, tumor size as well as the status of detoxification agents, lipid peroxidation and antioxidants. Oral squamous cell carcinomas were induced in the buccal pouch of Syrian golden hamsters by painting them with 0.5% DMBA in liquid paraffin three times a week for 14 weeks. We observed 100% oral tumor formation with severe histopathological abnormalities in all the hamsters treated with DMBA alone, activities of phase I and phase II detoxification enzymes, lipid peroxidation and antioxidants being significantly altered. Though oral administration of saffron completely prevented the formation of tumors, we noticed severe hyperplasia and dysplasia in hamsters treated with DMBA, suggesting that tumors might eventually develop. Oral administration of saffron return detoxification enzymes, lipid peroxidation and antioxidants to normal ranges. The chemopreventive potential of saffron thus is likely due to antioxidant properties and modulating effects on detoxification in favour of the excretion of carcinogenic metabolites during DMBA-induced hamster buccal pouch carcinogenesis.

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Section: Discussionmentioning

confidence: 99%

Saffron Reduction of 7,12-Dimethylbenz[a]anthracene-induced Hamster Buccal Pouch Carcinogenesis

Manoharan

Wani²,

Vasudevan³

et al. 2013

Asian Pacific Journal of Cancer Prevention

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“…The formation of PAH-DNA adducts (DNA binding products), a necessary step in PAH-initiated carcinogenesis, has been widely studied in experimental models and has been documented in human tissues 71 . According to previous studies, several nutrients such as vitamin A 72 73 , C 74 , D 75 76 and E 77 78 protect against the carcinogenic effects of DMBA exposure. The relatively low intake of these nutrients during the ICR-R period could cause a reduced protective effect, which may eventually lead to a relatively high tumor occurrence.…”

Section: Discussionmentioning

confidence: 92%

Effect of Intermittent versus Chronic Calorie Restriction on Tumor Incidence: A Systematic Review and Meta-Analysis of Animal Studies

Chen

Ling

et al. 2016

Sci Rep

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Both chronic calorie restriction (CCR) and intermittent calorie restriction (ICR) have shown anticancer effects. However, the direct evidence comparing ICR to CCR with respect to cancer prevention is controversial and inconclusive. PubMed and Web of Science were searched on November 25, 2015. The relative risk (RR) [95% confidence interval (CI)] was calculated for tumor incidence, and the standardised mean difference (95% CI) was computed for levels of serum insulin-like growth factor-1 (IGF-1), leptin, and adiponectin using a random-effects meta-analysis. Sixteen studies were identified, including 11 using genetically engineered mouse models (908 animals with 38–76 weeks of follow-up) and 5 using chemically induced rat models (379 animals with 7–18 weeks of follow-up). Compared to CCR, ICR decreased tumor incidence in genetically engineered models (RR = 0.57; 95% CI: 0.37, 0.88) but increased the risk in chemically induced models (RR = 1.53, 95% CI: 1.13, 2.06). It appears that ICR decreases IGF-1 and leptin and increases adiponectin in genetically engineered models. Thus, the evidence suggests that ICR exerts greater anticancer effect in genetically engineered mouse models but weaker cancer prevention benefit in chemically induced rat models as compared to CCR. Further studies are warranted to confirm our findings and elucidate the mechanisms responsible for these effects.

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“…The bark constituents are promising as anti-mutagenic and anti-carcinogenic remedy Needless to say that some species have important phytochemical compounds such as antioxidants, tannins, alkaloids, glycosides, which are useful in the treatment of coronary artery disease, cancer, etc. It is due to the fact that antioxidant contents are associated with the reduction of degenerative disease 3,11,24,25,26 .…”

Section: Terminalia Bellirica Roxbmentioning

confidence: 99%

“…The induction of oxidative stress is associated with cancer and cardiovascular disorders. Thus, it is likely that the high antioxidant contents of many Terminalia species may inhibit cancer formation and/or progression 3,7,9,12,16,25,28,29,30 . 3,5 .…”

Section: Antioxidant and Free Radical Scavengingmentioning

confidence: 99%

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2018

IJPSR

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Traditional medicines, derived from medicinal plants, are used by about 60% of the world's population. Plants of the genus Terminalia which consist of about 200-250 species are widely used as traditional medicine. The aim of this study was that review morphologic and toxonomic characteristics, pharmacological effects, traditional usage and products that derived of Terminalia in reports that published up to 2017. To conduct this review, the most up-to-date electronic journals including those indexed in the Pubmed, Elsevier, Institute for Scientific Information, Google Scholar and Scientific Information Database, databases and various books, has been used. Terminalia species have therapeutic effects such as cardiac stimulant effect that was compared with that of digoxin. Terminalia species possess several active phytochemicals with antioxidant activities. β-sitosterol is one of phytosterol compounds that has a therapeutic effect on inflammation by effect on prostacyclin I2 (PGI2) and prostaglandin E2 (PGE2). Other active phytochemical are tannins that have shown that tannins have strong anti-bacterial properties. Considering that many studies have been carried out on Terminalia plants in different fields and its beneficial effects in various diseases. To identify phytochemical compounds, further studies are required to fully determine the extent of use of medicinal plants and the phytochemistry of the genus Terminalia. In this review article can be a preliminary authentic source for the researchers to investigate the some unknown potential and therapeutic effects of these medicinal plants.

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Terminalia Arjuna (Roxb.) Modulates Circulatory Antioxidants on 7,12-dimethylbenz(a)anthracene- induced Hamster Buccal Pouch Carcinogenesis

Cited by 5 publications

References 29 publications

Saffron Reduction of 7,12-Dimethylbenz[a]anthracene-induced Hamster Buccal Pouch Carcinogenesis

Saffron Reduction of 7,12-Dimethylbenz[a]anthracene-induced Hamster Buccal Pouch Carcinogenesis

Effect of Intermittent versus Chronic Calorie Restriction on Tumor Incidence: A Systematic Review and Meta-Analysis of Animal Studies

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