Terminalia catappa reverses insulin resistance, improves glucose transport and activates PI3K/AKT signalling in high fat/ streptozotocin-induced diabetic rats

Iheagwam, Franklyn Nonso; Iheagwam, Olawumi Toyin; Onuoha, Michael Kemjika; Ogunlana, Olubanke Olujoke; Chinedu, Shalom Nwodo

doi:10.21203/rs.3.rs-1482587/v1

Cited by 1 publication

(1 citation statement)

References 37 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Depending on the stage and severity of the PCa, ADT may be used alone or in conjunction with other therapies like radiation therapy or chemotherapy. Despite the fact that ADT can be helpful in symptom improvement and slowing the spread of PCa, all patients eventually develop deadly metastatic CRPC [62,78]. As a result, secondgeneration hormonal treatments have substantially improved the prognosis for those with advanced PCa.…”

Section: Emerging Therapies Targeting Armentioning

confidence: 99%

Unlocking the Secrets of Androgen Receptors in the Susceptibility, Progression, and Treatment of Prostate Cancer

Zakari,

Ekenwaneze,

Amadi

et al. 2023

Preprint

View full text Add to dashboard Cite

Prostate cancer (PCa) is a major cause of cancer-related mortality worldwide, with a rising incidence observed over the years. The androgen receptor (AR) signaling pathway plays a pivotal role in male development and maintaining masculine characteristics. Dysregulation of AR signaling in prostate cancer can lead to disease progression and resistance to standard therapies. Understanding the intricate regulation and function of AR in both healthy and diseased states is crucial for developing effective treatment strategies. This review comprehensively explores the role of androgen receptors in prostate cancer susceptibility, disease progression, and treatment response by analyzing recent literature. An extensive search of peer-reviewed publications in major databases, including PubMed, Scopus, and Web of Science, was conducted using specific keywords related to androgen receptor, prostate cancer, disease progression, and treatment resistance. Relevant conference abstracts and clinical trial reports were also included. The review presents an overview of the role of androgen receptors in prostate cancer initiation, progression, and treatment resistance. It highlights emerging biomarkers associated with AR signaling dysregulation and their potential utility for early detection and personalized treatment approaches. Additionally, recent advances in targeting the AR pathway for novel therapeutic strategies to improve patient outcomes and overcome treatment resistance in advanced prostate cancer are discussed. The findings contribute to a comprehensive understanding of the AR signaling pathway in prostate cancer and offer insights into its multifaceted role in disease development and treatment response. They may pave the way for innovative therapeutic interventions and precision medicine approaches based on specific AR signaling profiles, enhancing patient care and reducing the burden of this lethal disease.

show abstract

Section: Emerging Therapies Targeting Armentioning

confidence: 99%