Terminalia muelleri Attenuates the Accumulation of Excess Iron, Inhibition of Topoisomerase 2ß and Oxidative Cardiac Damage in Doxorubicin-Induced Cardiotoxicity in Rats

Abstract

C ardiovascular system dysfunction is one of the most frequent consequences of exposure to antineoplastic treatment, whereas cardiovascular diseases and cancers are the leading causes of morbidity and mortality in the world (Sung et al., 2021). The less regeneration ability of cardi-ac cells renders cardiac myocytes to be more prone to the long-term adverse effects of chemotherapy agents such as anthracycline (Hardaway, 2019).Cardiotoxicity is the toxicity that affects the heart. This definition is attributed to the effect of chemotherapy on the entire cardiovascular system that occurs through di-