A lthough effective results are attained with paroxysmal atrial fibrillation (AF) ablation based on pulmonary vein isolation (PVI), catheter ablation of persistent AF remains a challenging task. Current ablation approaches in persistent AF ablation are markedly diverse, and there is a considerable variation in the reported clinical outcomes.1 Moreover, the lack of a distinct procedural end point makes comparison between the studies difficult.
Response by Latchamsetty and Oral on p 971Recently, significant advances have been made with the development of novel technologies, such as computational mapping and panoramic noninvasive mapping to map drivers (rotors and focal discharges) during AF. The advent of these newer technologies and strategies for persistent AF ablation further raise the question as to whether AF termination should be the procedural end point, and whether it confers additional long-term clinical benefit.In this article, we review the current evidence on AF termination and long-term clinical outcome, procedural AF termination as a predictor of freedom from recurrent atrial arrhythmias, AF termination rates with various ablation strategies, and potential underlying mechanisms conferring clinical benefit and future directions.
AF Termination and Clinical Outcome Search StrategyThe English scientific literature in the PubMed database was searched using the terms catheter ablation, persistent AF, and termination in any region of the PubMed record until October 2014. Studies that described procedural AF termination rates during ablation together with clinical outcomes after ablation for patients with persistent AF or long-standing persistent AF were included. References from the relevant articles were reviewed to identify further related articles. Definition of AF termination included direct conversion to sinus rhythm (SR) and organization to atrial tachycardia (AT) during ablation.