Termination of pathological pregnancy in second and early third trimesters with extraamniotic instillation of 16-phenoxy-ω-tetranor prostaglandin E<sub>2</sub>methylsulfonylamide

The efficacy and safety of intracervical placement of laminaria and intravenous prostaglandin E2 (sulprostone) infusion for termination of second-trimester pregnancies with abnormal fetuses was investigated. One hundred and six pregnant women at 13-29 weeks' gestation with fetal anomalies underwent laminaria tent insertion into the cervical canal on admission. The next morning, Sulprostone infusion was started at a rate of 16 microg/h and increased by 16 microg/h every 30 min to induce uterine contractions. Induction-to-abortion time (IAT), success and complete abortion rates, and sulprostone-related side effects were registered. The overall success and complete abortion rates within 24 h were 91.5 and 80.2%, respectively. The mean IAT was 12.1+/-7.6 h. The incidence of nausea and/or vomiting was 17.9%, with 1.7 episodes per case. Diarrhea and fever (9.5%) were not common. Laminaria tent insertion plus sulprostone infusion was an effective and safe regimen for second-trimester termination of pregnancy with live fetuses.

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Laminaria and sulprostone in second trimester pregnancy termination for fetal abnormalities

Chung

Hwa

1999

Intl J Gynecology & Obste

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Termination of pathological pregnancy in second and early third trimesters with extraamniotic instillation of 16-phenoxy-ω-tetranor prostaglandin E₂methylsulfonylamide

Abstract: To the best of our knowledge, this is the first report in the English literature of administration of sulprostone by extraamniotic instillation for termination of pathological pregnancies. The method is effective and safe and has an insignificant influence on subsequent fertility.

Cited by 1 publication

References 13 publications

Laminaria and sulprostone in second trimester pregnancy termination for fetal abnormalities

Laminaria and sulprostone in second trimester pregnancy termination for fetal abnormalities

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Termination of pathological pregnancy in second and early third trimesters with extraamniotic instillation of 16-phenoxy-ω-tetranor prostaglandin E2methylsulfonylamide

Abstract: To the best of our knowledge, this is the first report in the English literature of administration of sulprostone by extraamniotic instillation for termination of pathological pregnancies. The method is effective and safe and has an insignificant influence on subsequent fertility.

Cited by 1 publication

References 13 publications

Laminaria and sulprostone in second trimester pregnancy termination for fetal abnormalities

Laminaria and sulprostone in second trimester pregnancy termination for fetal abnormalities

Contact Info

Product

Resources

About

Termination of pathological pregnancy in second and early third trimesters with extraamniotic instillation of 16-phenoxy-ω-tetranor prostaglandin E₂methylsulfonylamide