Termination of pregnancy for fetal anomaly

Aslan, Halıl; Yıldırım, Gökhan; Ongut, C.; Ceylan, Yavuz

doi:10.1016/j.ijgo.2007.05.047

Cited by 31 publications

(45 citation statements)

References 13 publications

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“…İkincil olarak, hastaların tersiyer merkezlere uygun zamanda transferini gerçek-leştirerek, bebeklerin daha iyi bir postnatal bakım almasını sağlamaktır. Ayrıca ebeveynlere gebeliği sonlandırma seçeneğini ülkenin resmi yasaları çer-çevesinde ve tanımlanmış koşulların varlığında sunmaktır (2) . Fetal anomali nedeniyle uygulanan terminasyonun, ebeveynler açısından, etik ve psikolojik olarak kabul edilebilirliği erken gebelik haftalarında daha fazladır (3) .…”

Section: Introductionunclassified

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Late termination of pregnancy due to fetal abnormalities: An analysis of 229 cases

Tayyar¹,

Açar²,

Turhan³

et al. 2017

IKSST

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Section: Introductionunclassified

“…Terminasyon için yasal gebelik haftası sınırı, ülkeler arasında farklılık göstermekte-dir (2) . Bazı ülkelerde yasalar, fetal anomaliye bağlı terminasyon için gebelik haftası sınırlaması getirmez iken, bazılarında ise terminasyon yasaklanmıştır (1) .…”

Section: Introductionunclassified

Late termination of pregnancy due to fetal abnormalities: An analysis of 229 cases

Tayyar¹,

Açar²,

Turhan³

et al. 2017

IKSST

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“…The laws on performing TOP vary between countries, and may specify: 1) no upper gestational age limit for any TOP, 2) no upper gestational age limit for lethal anomalies, 3) an upper gestational age limit for any TOP, 4) no TOP at any gestational age (2). Since 1983, Turkish law has permitted the TOP at any period of gestation if the ongoing pregnancy is hazardous for a woman's health and/or fetus has a high risk of severe disability or incurable fatal disease (3). Approval for the TOP can be given by two specialists when there is a maternal or fetal reason justifying the TOP.…”

Section: Introductionmentioning

confidence: 99%

Trends in fetal indications for termination of pregnancy between 2002 and 2010 at a tertiary referral centre

Çorbacıoğlu¹,

Aslan²,

Aydın³

et al. 2012

J Turkish German Gynecol Assoc

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Objective:We reviewed the data of the termination of pregnancy (TOP) cases between 2002 and 2010 to evaluate the changes in fetal indications for both early and late TOPs in this period. Material and Methods:The data of 962 TOP cases were analysed in two groups according to the periods as in 2002-2006 and 2007-2010. The women were also subdivided into two categories according to their gestational age; <23 weeks' gestation (early termination) and ≥23 weeks' gestation (late termination).Results: Four hundred and fifty-eight (47.6%) of TOPs were performed between 2002 and 2006 (Group 1) and 504 (52.3%) were performed between 2007 and 2010 (Group 2). The number of early (<23 weeks) and late (≥23 weeks) terminations were 583 (60.6%) and 379 (39.3%), respectively. The vast majority of anomalies were central nervous sytem malformations (51.8%). They were followed by multiple anomalies (10.2%) and chromosomal anomalies (9.4%). Chromosomal and cardiovascular system anomalies were significantly higher in 2007-2010 in comparison to 2002-2006 (p<0.0001 and p=0.002, respectively). There was no statistically significant difference between the fetal indications that led to early termination compared to those that led to late termination. Conclusion:The distribution of indications for TOP was influenced by the development in prenatal screening policy, resulting in a significant increase in terminations due to chromosomal and cardiovascular system anomalies. Cultural, educational, religious and legal factors cause differences in the indications for TOP as well as the gestational age that TOPS are performed. Sonuç: Terminasyon endikasyonlarının dağılımı prenatal tarama politikalarındaki gelişimden etkilenmiş, buna bağlı olarak kromozom ve kardiyovaskuler sistem anomalileri nedeniyle yapılan terminasyonların sayısı önemli ölçüde artmıştır. Kültürel, eğitimsel, dini ve yasal faktörler terminasyon yapıldığı gebelik haftasının yanı sıra terminasyon endikasyonlarında da değişikliklere yol açmaktadır. (J Turkish-German Gynecol Assoc 2012; 13: 85-90)

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“…The malformations constitute the most frequent indication for termination of pregnancy. This group include different pathologies in which skeletal system is a small percentage variable between 6% and 16% [30][31][32]. Although most of the TA referred to our laboratory came from private centre with no medical or anatomic record, we have diagnosed 30% of TA (5 skeletal dysplasias and 1 triploidy) from 20 cases.…”

Section: Discussionmentioning

confidence: 99%

“…Chromosomal abnormalities are the second cause of foetal anomalies so cytogenetic/molecular studies must be done [29,30]. The malformations constitute the most frequent indication for termination of pregnancy.…”

Section: Discussionmentioning

confidence: 99%

Prenatal diagnosis of skeletal dysplasia due to FGFR3 gene mutations: a 9-year experience

Trujillo-Tiebas

Fenollar-Cortés

Lorda‐Sánchez

et al. 2009

J Assist Reprod Genet

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Purpose Prenatal diagnosis with ultrasound findings compatible with skeletal dysplasia due to FGFR3 mutations over a 9 year period in pregnancies and abortuses. Methods 54 samples were studied. Aneuploidy studies were carried out on all samples. By sequencing analysis, we determined mutations for achondroplasia (ACH), hypochondroplasia (HCH), and type I and type II tanathophoric dysplasia (TD). Results 2 chorionic villi samples had a G380R mutation due to a mother with ACH; 4 amniotic fluid samples with TDs in which the foetuses had micromelia plus hypoplastic thoraces; 5 samples from abortuses with TDs. Neither ACH nor HCH occurred in sporadic cases. Conclusions Molecular studies in ongoing pregnancies are indicated in cases with an affected parent, a family history with positive molecular studies (maternal anxiety), and when the US finding demonstrates micromelia with a hypoplastic thorax. A protocol for tissues of abortuses should include an X-ray, pathologic anatomy, and genetic studies.

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Termination of pregnancy for fetal anomaly

Abstract: A substantial proportion of TOPs for fetal anomaly beyond 22 weeks of gestation could have been performed earlier with timely diagnosis.

Cited by 31 publications

References 13 publications

Late termination of pregnancy due to fetal abnormalities: An analysis of 229 cases

Late termination of pregnancy due to fetal abnormalities: An analysis of 229 cases

Trends in fetal indications for termination of pregnancy between 2002 and 2010 at a tertiary referral centre

Prenatal diagnosis of skeletal dysplasia due to FGFR3 gene mutations: a 9-year experience

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