Terminology of the prostate and related structures

Wendell-Smith, C. P.

doi:10.1002/(sici)1098-2353(2000)13:3<207::aid-ca9>3.0.co;2-9

Cited by 17 publications

(4 citation statements)

References 17 publications

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“…In the rat prostate, based on their relationship to the urethra, four histological zones – anterior, central, peripheral and transitional – have been reported (McNeal, ; Wendell Smith, ). According to Sluczanowska‐Glabowska et al.…”

Section: Discussionmentioning

confidence: 99%

Anatomical and Immunohistochemical Characteristics of the Prostate Gland in the Greater Cane Rat (Thryonomys swinderianus)

Adebayo

Akinloye

Olukole

et al. 2014

Anat. Histol. Embryol.

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This study examined the morphology and immunohistochemical features of the prostate gland in 15 captive-reared male greater cane rat of known reproductive and medical history. Samples of the glands were taken after gross examination and routinely prepared for both histological and ultrastructural analysis. Immunohistochemistry was also carried out on paraffin-embedded sections of the glands using rabbit polyclonal antibodies against oestrogen receptors (ERα and ERβ) and mouse monoclonal antibody for the progesterone receptor (PR). The prostate, which constitutes 0.04% of the body weight, was a paired, lobulated, brownish gland having three left and four right lobes that partly cover the pelvic urethra. Based on the amount and arrangement of the secretory epithelial folding and relative to their distances to the urethra, two histological zones, the central and peripheral, were identified. However, the epithelium of both zones was lined by predominantly simple cuboidal cells with occasional basal cells. The main ultrastructural features of these cuboidal cells were the presence of several nuclear pores on the nucleus, moderately well-developed, short microvilli and bleb-like apical projections, as well as inter-cellular lacunae seen between these cells and the basal cells. The cuboidal epithelial cells also showed positive nuclear staining for ERα and ERβ but not for PR. It is however interesting that the ERα-positive staining was more at the epithelial cells, which is uncommon. These findings highlight the peculiarities in the structure and ultrastructure as well as the unique expression of the oestrogen receptors in the prostate gland of the greater cane rat.

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Section: Discussionmentioning

confidence: 99%

Anatomical and Immunohistochemical Characteristics of the Prostate Gland in the Greater Cane Rat (Thryonomys swinderianus)

Adebayo

Akinloye

Olukole

et al. 2014

Anat. Histol. Embryol.

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“…While the specific etiology of BPH is largely unknown, several cellular processes have been reported to be involved in BPH initiation and development. BPH disrupts growth regulation and homeostatic control of proliferative and apoptotic behavior in the periurethral and transition zones, resulting in uncontrolled proliferation and migration of prostatic epithelium and enlargement of the cell proliferating compartment [ 3 , 4 ]. Furthermore, increased mesenchymal-like cells derived from the prostatic epithelium via epithelial-mesenchymal transition (EMT) also contribute to BPH development [ 5 – 7 ].…”

Section: Introductionmentioning

confidence: 99%

METTL3 promotes prostatic hyperplasia by regulating PTEN expression in an m6A-YTHDF2-dependent manner

Yao

Huang

et al. 2022

Cell Death Dis

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Uncontrolled epithelial cell proliferation in the prostate transition zone and the hyper-accumulation of mesenchymal-like cells derived from the epithelial-mesenchymal transition (EMT) of prostatic epithelium are two key processes in benign prostatic hyperplasia (BPH). m6A RNA modification affects multiple cellular processes, including cell proliferation, apoptosis, and differentiation. In this study, the aberrant up-regulation of methylase METTL3 in BPH samples suggests its potential role in BPH development. Elevated m6A modification in the prostate of the BPH rat was partially reduced by METTL3 knockdown. METTL3 knockdown also partially reduced the prostatic epithelial thickness and prostate weight, significantly improved the histological features of the prostate, inhibited epithelial proliferation and EMT, and promoted apoptosis. In vitro, METTL3 knockdown decreased TGF-β-stimulated BPH-1 cell proliferation, m6A modification, and EMT, whereas promoted cell apoptosis. METTL3 increased the m6A modification of PTEN and inhibited its expression through the reading protein YTHDF2. PTEN knockdown aggravated the molecular, cellular, and pathological alterations in the prostate of BPH rats and amplified TGF-β-induced changes in BPH-1 cells. More importantly, PTEN knockdown partially abolished the improving effects of METTL3 knockdown both in vivo and in vitro. In conclusion, the level of m6A modification is elevated in BPH; the METTL3/YTHDF2/PTEN axis disturbs the balance between epithelial proliferation and apoptosis, promotes EMT, and accelerates BPH development in an m6A modification-related manner.

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“…Na espécie humana, encontra-se logo abaixo da bexiga, circundando a primeira porção da uretra, sendo a uretra prostática. Segundo a Nômina Internacional Anatômica de 1989, as regiões prostáticas são: base, ápice, lobos médio direito e esquerdo e istmo 4 . Estudos clínicos utilizam a divisão em zonas da próstata sendo essas: central, fibromuscular, periférica, de transição e periuretral.…”

Section: -Introdução 11-arquitetura E Citologia Prostáticaunclassified

“…Estudos clínicos utilizam a divisão em zonas da próstata sendo essas: central, fibromuscular, periférica, de transição e periuretral. Figura 1 4,5 .…”

Section: -Introdução 11-arquitetura E Citologia Prostáticaunclassified

Impacto do exame retal digital da próstata no PSA como gatilho de biópsia da próstata

Moreira da Silva Junior

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Primeiramente gostaria de agradecer a Deus, que conduz minha vida e da minha família, toda honra e toda glória à Ele. A minha família, minha amada esposa Ana Paula, que esbarra na perfeição e contribui, de forma inenarrável, ao meu crescimento tanto pessoal quanto profissional e minha queria filha, Ana Laura, que me inspira todos os dias. Amo muito vocês duas.Aos meus pais, Maurício e Maria Elizabeth, que com muito trabalho me ensinou os princípios de uma vida digna e correta, me ensinando a andar em todos os sentidos, assim como meu sogro Luiz Carlos e minha sogra Deolinda, que em momentos difíceis me estimularam a concluir mais esta etapa da minha vida.Ao meu amigo e Prof. Leonardo Oliveira, que com simplicidade e competência faz parecer fácil realizar pesquisa neste país. Ao meu grupo de trabalho, Prof. Dr. Marcelo Lopes, que admiro pela retidão e profissionalismo e Dr. Nilson, que são grandes amigos, que tenho a honra de dividir minha vida profissional ao lado deles, juntamente com minha instrumentadora Débora e as minhas amigas e colaboradoras, Edinea e Rafaela, muito obrigado. Aos meus amigos que guardo no coração, que sei que posso contar nos momentos difíceis, Romulo Zanco, que me apoia e ajuda em todos os momentos, Mario Sérgio, sempre preocupado com a política e que me fortalece no dia a dia, Marco Bosoni, preocupado com os investimentos, Francisco que me transmite sempre calma e tranquilidade e Cristiano Trindade, meu grande amigo e que gosto muito.Ao Pastor da minha igreja, Pastor Ernesto, que me ajuda, ao lado da palavra de Deus, o meu crescimento espiritual.

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Terminology of the prostate and related structures

Cited by 17 publications

References 17 publications

Anatomical and Immunohistochemical Characteristics of the Prostate Gland in the Greater Cane Rat (Thryonomys swinderianus)

Anatomical and Immunohistochemical Characteristics of the Prostate Gland in the Greater Cane Rat (Thryonomys swinderianus)

METTL3 promotes prostatic hyperplasia by regulating PTEN expression in an m6A-YTHDF2-dependent manner

Impacto do exame retal digital da próstata no PSA como gatilho de biópsia da próstata

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