Terms of immunity formation in sheep vaccinated with a combined vaccine against peste des petits ruminants and sheeppox

Abstract

The article presents the results of studies to determine the timing of the onset of immunity in sheep vaccinated with the associated vaccine against peste des petits ruminants (PPR) and sheep pox (SP). The timing of the onset of immunity in vaccinated animals against PPR and SP was evaluated by serum neutralization test (SNT) and by testing the withstood of vaccinated sheep to challenge infection with virulent strain "A" of SP virus. Protective tiers of virus neutralizing antibodies (VNA) to the PPRV virus were formed on 14 days with an average value of 2.8 log2 and reached up to 4.7 log2 on 21 days after vaccination, while immunity against the OO virus was formed on 7 days after vaccination with an average VNA titer of 1.8 log2, which increased to 4.3 log2 on 21 days after vaccination. All immunized sheep’s showed resistance to the virulent SP virus until the end of the experiment. Therefore, the experimental data obtained by us indicate a high degree of protection of animals immunized with the associated vaccine against PPR and SP, starting from day 7 from the SP virus and from day 14 from the PPR virus. Key words: combined vaccine, peste des petits ruminants, sheep pox, immunity.

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“…Thus, M. Munibul The outbreak of the disease among farm animals, according to J. Amanova et al (2020), leads to significant economic losses, which are associated with the death or forced slaughter of infected animals, a decrease in their productivity, losses on veterinary, sanitary, and quarantine measures. Therefore, the most common method of preventing this viral disease is active immunisation of all susceptible livestock .…”

A sporadic case of small ruminant plague in sheep: morphological and functional manifestation of cellular and humoral immunodeficiency

“…Thus, M. Munibul The outbreak of the disease among farm animals, according to J. Amanova et al (2020), leads to significant economic losses, which are associated with the death or forced slaughter of infected animals, a decrease in their productivity, losses on veterinary, sanitary, and quarantine measures. Therefore, the most common method of preventing this viral disease is active immunisation of all susceptible livestock (Bayantassova et al, 2023).…”