Granite powder (stone powder), a waste product generated from stone quarries, is increasingly being reused in cement-treated clays. The particle size of stone powders affects the cement-clay reaction by either increasing or reducing the unconfined compressive strength (UCS). This study investigated this phenomenon by separating stone powder from the same batch at the quarry into five particle sizes (A, B, C, D and E: 106–75 µm, 40–75 µm, 20–40 µm, <20 µm and 106–<1 µm, respectively). Flow value, fall cone, UCS and thermogravimetry-differential thermal analysis (TG-DTA), X-ray fluorescence, electrical conductivity and NaOH digestion tests were conducted. It was discovered that stone powder had an amorphization rate of up to 1.45 % (14.5 mg/g of amorphous silica); hence, it was pozzolanic. However, the amorphousness varied with the particle size of the material in the order of D > E > C > B > A, which translated into UCS variation in the same order. Stone powders D and E played two roles in UCS development, i.e., nucleation of cementitious products and reaction with Ca(OH)2 to increase the UCS higher than the control sample. Linear regression equations determined the minimum concentration of amorphous silica for a UCS increment as 9.4 mg/g.