Ternary complexes as models for protein-metal-nucleic acid interactions: structure of palladium(II) complex with glycyl-L-tyrosine and cytidine

Abstract

The structure of the palladium(II) complex with glycyl-L-tyrosine and cytidine, Pd(Gly-L-Tyr)(Cyd)-6.5H20 (C2oH25N509Pd'6.5H20), has been determined from X-ray diffraction data. The compound crystallizes in orthorhombic space group D2%-I222 with unit cell parameters a = 15.433

Synthesis, structural characterization, in vitro antimicrobial and anticancer activity studies of ternary metal complexes containing glycine amino acid and the anti-inflammatory drug lornoxicam

“…In addition, the importance of metal complexes derived from amino acids comes not only from inorganic point of view but because of the possible biological interest [3][4][5][6]. Grosser has shown that amino acids exert antioxidant action [4].…”

Synthesis and characterization of mixed ligand complexes of lomefloxacin drug and glycine with transition metals. Antibacterial, antifungal and cytotoxicity studies

“…1 Â 10 À3 M Stock solutions of the metal salts (Fe(III), 0.27 g/l; Co(II), 0.23 g/l; Ni(II), 0.23 g/l; Cu(II), 0.17 g/l; Zn(II), 0.172 g/l; Cr(III), 0.26 g/l; UO 2 (II), 0.50 g/l, Mn(II), 0.16 g/l and Th(IV), 0.37 g/l) were prepared by dissolving the accurately weighed amounts of the metal salts in the appropriate volume of de-ionized water. Acid mixture (0.04 M phosphoric, acetic and boric acids) from which series of universal buffer solution of different pH values (2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12) were prepared by using 0.1 M sodium hydroxide solution for adjusting the desired pH.…”

“…6A 1g transitions, respectively, which suggests an octahedral geometry [32,33]. From the diffused reflectance spectrum, it is observed that, the Fe(III) chelate exhibits a band at 21,512 cm À1 , which may be assigned to the 6 A 1g ? T 2g (G) transition in octahedral geometry of the complex [23,32].…”

“…Metal ion-mediated reactions involving nucleic acid constituents and amino acid side chains have been the subject of several investigations [1][2][3][4][5][6]. These reactions provide an opportunity to identify the nature of such interactions in vivo as they serve as models for many metalloenzyme reactions.…”

Metallkomplexe mit biologisch wichtigen Liganden, CXXVIII [1], Palladium(II)-Komplexe mit deprotonierten Peptidestern als N,N′-Chelatliganden / Metal Complexes with Biologically Important Ligands, CXXVIII [1]. Palladium(II) Complexes with Deprotonated Peptide Esters as N,N′-Chelate Ligands

“…Verschie dene Peptid-Palladium(II)-Komplexe mit der Ami nogruppe und der deprotonierten Amidfunktion als Chelat-Liganden wurden auch röntgenogra phisch gesichert [14]. Besonders einfache Beispie le sind die Bischelat-Komplexe Pd(Dipeptidester-H+)2 [12]; sie sind Vorläufer für die Cyclo-Kondensation zu Cyclotetrapeptiden am Palladium(II).…”