The present article exploits a novel application of AI-based Levenberg–Marquardt scheme with backpropagated neural network (LMS–BPNN) to analyze the double-diffusive free convection nanofluid flow model (DDFC-NFM) over an inclined plate in the existence of Brownian motion and thermophoresis properties embedded in a porous medium. The governing PDEs representing DDFC-NFM are transformed into system of nonlinear ODEs by applying suitable transformation. The reference data set is generated from Lobatto III-A numerical solver by variation of magnetic field parameter (
M
), thermal Grashof number (Gr), angle of inclination (
α
), Brownian motion parameter (Nb), Dufour-solutal Lewis number (Ld), modified Dufour parameter (Nd) and thermophoresis parameter (Nt) for all scenarios of the designed LMS–BPNN. The approximate solution and its comparison with standard solution are analyzed by execution of training, testing and validation procedure of the designed LMS–BPNN. The effectiveness and reliable performance of LMS–BPNN are endorsed with MSE-based fitness curve, regression analysis, error histogram analysis and correlation index. Results reveal that velocity increases with the rise in
Gr,
whereas reverse trend has been noticed for angle of inclination and magnetic field parameter and the temperature profile increases with the increase in Nb, Nd and Nt. The solutal concentration profile increases with the increment in Ld, while an increase in Nd causes a decrease in it. When Nt increases, the enhancement in the nanoparticle volume frictions occurs, but an opposite behavior is depicted for Brownian motion parameter.