Terpene compounds as drugs. 11. Anabolic 19-nortestosterone terpenoates

Pala, G; Casadio, S; Mantegani, A; Bonardi, G; Coppi, G

doi:10.1021/jm00279a031

Cited by 9 publications

(1 citation statement)

References 2 publications

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“…2-Iminothiazolines are characterized by a wide range of biological properties [9][10][11][12]. The thiazolidene-2-imine [13] or thiazol-2-imine [14] or 2iminothiazoline [15][16][17][18] ring system, as it has been named by different groups, is present in several drug candidates possessing interesting biological activities such as muscarinomimetic, antimycotic, hypolipemic, antidiabetic, thrombopoietinagonism, cell adhesion antagonists, platelet GPIIb/IIIa receptorantagonists, anti-inflammatory, analgesic and kinase (CDK1, CDK5 and GSK3) inhibition, schistosomicides, cadiotonicsand trichomonides [19][20][21][22][23]. Thiazoline derivatives have been found to exhibit promising applications in agriculture, such as acaricides, insecticides, and plant growth regulators [24,25].…”

Section: Introductionmentioning

confidence: 99%

Computer prediction and synthesis of new azoles based on N-benzoyl-N'-(9,10-dioxo-9,10-dihydroanthracen-1-yl)thioureas

et al. 2014

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New thiazole and 1,2,4-triazole derivatives of 9,10-anthraquinone were obtained by the reaction of N-benzoyl-N'-(9,10dioxo-9,10-dihydroanthracene-1-yl)-thioureas with bromoacetone in the presence of triethylamine and hydrazine hydrate in chloroform, respectively. The PASS computer program was used to predict the biological activity spectra and to determine the most promising biological activities for experimental testing. Thus, it has been shown that the synthesized compounds are a promising class for the creation of substances with a wide range of biological activity.

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Section: Introductionmentioning

confidence: 99%

Computer prediction and synthesis of new azoles based on N-benzoyl-N'-(9,10-dioxo-9,10-dihydroanthracen-1-yl)thioureas

et al. 2014

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ChemInform Abstract: TERPEN‐VERBINDUNGEN ALS PHARMACA 11. MITT. ANABOLISCHE 19‐NORTESTOSTERONTERPENOATE

Pala¹,

Casadio²,

Mantegani³

et al. 1973

Chemischer Informationsdienst

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Efficient Electrosynthesis of Thiazolidin‐2‐imines via Oxysulfurization of Thiourea‐Tethered Terminal Alkenes Using the Flow Microreactor

et al. 2018

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Sulfur‐containing scaffolds play a significant role in many important biological processes. The thiazole‐2‐imine derivatives have gained significant biological attention due to their interesting pharmacological activities and act as potential therapeutic agents. Many of their syntheses suffer from the drawbacks such as the handling of toxic reagents, harsh reaction conditions, longer reaction times and tedious separation procedures. To their easy access, we applied first time flow electrochemical approach under free supporting electrolytes conditions and without the use of expensive catalysts and reagents. This is not only the first electrochemical cyclization to access thiazolidin‐2‐imines also represents the first intramolecular sulfurization of unfunctionalized terminal alkenes. This flow electrolysis of N‐allylic thioureas generates radical intermediates of nitrogen and sulfur that cyclized via oxysulfurization of terminal alkenes and gives thiazolidin‐2‐imines with good to high yields under mild, green and environmentally friendly conditions.

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Terpene compounds as drugs. 11. Anabolic 19-nortestosterone terpenoates

Cited by 9 publications

References 2 publications

Computer prediction and synthesis of new azoles based on N-benzoyl-N'-(9,10-dioxo-9,10-dihydroanthracen-1-yl)thioureas

Computer prediction and synthesis of new azoles based on N-benzoyl-N'-(9,10-dioxo-9,10-dihydroanthracen-1-yl)thioureas

ChemInform Abstract: TERPEN‐VERBINDUNGEN ALS PHARMACA 11. MITT. ANABOLISCHE 19‐NORTESTOSTERONTERPENOATE

Efficient Electrosynthesis of Thiazolidin‐2‐imines via Oxysulfurization of Thiourea‐Tethered Terminal Alkenes Using the Flow Microreactor

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