Terpene compounds as drugs. VI. Acyclic mono- and sesquiterpene thiocyanates and isothiocyanates

Progress in the Experimental Chemotherapy of Helminth Infections; Part I, Trematode and Cestode Infections

“…nana [314], while 4-[(2-hydroxyethyl)amino]-2-(5-nitro-2-thienyl)quinazoline (CXLVII), the most active of a series of nematocidal nitrothienylquinazolines, was reported to cause a 100% reduction in Hymenolepis nana in mice when administered at 25 mg/kg twice a day for 3 days [315]. In addition to some in vitro antiprotozoal activity, nitro-derivatives of arylsydnones CXL VIII were effective against H. nana in mice, showing taenicidal activity only a little inferior to that of quinacrine [316]. From an examination of 30 nitrated heterocyclic compounds, it was shown that 6-nitroindazole, 5-nitroindole, 5-nitrobenzotriazole, and 5-nitroisatin had some III VIVO activity against H. nana [317].…”

Studies on Synthesis of Some New Sydnone Containing Compounds and Their Biological Activities

“…Various elecrophilic substitution reactions such as halogenation [4][5][6][7] , nitration 8 , acylation 9,10 , sulphonation 11 occur at the fourth position of the sydnone ring containing a hydrogen atom 12 . Sydnone derivatives have been the focus of great interest because of their remarkable biological properties [13][14][15] , such as antibacterial 16,17 , antitumor 18,19 , antifungal 20,21 , antimalarial [22][23][24] , antiparasitic 25 , analgesic 26 , antioxidant 27 , anti inflammatory 28 . Sydnone derivatives also show significant response of coronary dilation test, collagen induced platelet aggregation inhibition, local anaesthetic, antiwrithing, anticonvulsant, muscle relaxation and moderate cardio tropic activity 29 .…”

An Easy Direct Arylation of 3-Arylsydnones

“…These compounds have long attracted considerable interest in the field of chemical synthesis, and thus their chemistry has been widely studied. 1 Over the years, numerous sydnone compounds have been prepared or investigated because of their biological values as antibacterial, 2 antitumor, 3 antimalarial, 4 anti-inflammatory, 5 antihypertensive, analgesic, and antipyretic 6 activities. These compounds can also be used as liquid crystals 7 and electrolytic solvents.…”