Terpene ligands in the coordination chemistry: synthesis of metal complexes, stereochemistry, catalytic properties and biological activity

Abstract

Published data on the synthesis and catalytic properties of metal complexes with chiral ligands containing a terpene moiety are integrated and systematized. The stereochemical features of transition metal complexes with terpene ligands are discussed. Structures of stable complexes of this type and the initial chiral ligands are presented. In view of the enormous structural diversity of the analyzed data, classification is based on the chemical functionality of terpene ligands. The results of application of terpene ligands in asymmetric transition metal catalysis are considered; the data are classified in terms of the type of chemical reaction. Data on the biological activity of some metal complexes with terpene ligands are presented. The bibliography includes 228 references.

Copper(ii) complexes with terpene derivatives of ethylenediamine: synthesis, and antibacterial, antifungal and antioxidant activity

“…Terpene ligands are successfully used in coordination chemistry for the synthesis of chiral metal complexes. 27 In our work, we used terpene derivatives of ethylenediamine L1–L4 as polydentate ligands for the preparation of copper chelate complexes ( Fig. 1 ).…”

Direct Reductive Amination of Camphor Using Iron Pentacarbonyl as Stoichiometric Reducing Agent: Features and Limitations

“…Terpenoids are an irreplaceable class of natural products as well as chemical motifs. The camphoryl group is an important moiety in the structure of chiral ligands for asymmetric catalysis or it can be used as an auxiliary group in asymmetric synthesis . The usage of fenchone based molecules for asymmetric catalysis and synthesis is less common because of the difficulty of fenchone modifications due to steric hindrance , .…”

“…The camphoryl group is an important moiety in the structure of chiral ligands for asymmetric catalysis or it can be used as an auxiliary group in asymmetric synthesis. [1][2][3][4][5][6] The usage of fenchone based molecules for asymmetric catalysis and synthesis is less common because of the difficulty of fenchone modifications due to steric hindrance. [7,8] Camphor is a readily available starting molecule for the preparation of different compounds with biological activity.…”

Antimicrobial and Antifungal Activities of Terpene-Derived Palladium Complexes

“…The three types of chiral palladium complexes studied in the present work were derived from the natural terpenoids (−)-α-pinene, (+)-α-pinene, (−)-camphor, and (+)-camphor, with the N-donor atom in each complex originating from (−)-(s)-α-methylbenzylamine (compounds 1, 4, and 5), benzhydrylamine (compounds 2 and 3), or ethylenediamine (compounds 6-12) (Figures 1 and 2). Chiral metal complexes with terpene ligands are actively studied in various asymmetric transformations [28]. Complexes 1-4 are palladacycles containing a carbon-palladium bond obtained by direct cyclopalladation of the benzylamine moiety ( Figure 1).…”