Terpenes

Wiart, Christophe

doi:10.1016/b978-0-12-398371-8.00002-7

Cited by 11 publications

(7 citation statements)

References 474 publications

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“…Terpenes, one of the most extensive and varied structural group of compounds occurring in nature, display a wide range of biological and pharmacological activities and strong antioxidant property [28]. Wiart [29] has reported that the terpenes compromise the cell cycle in different types of malignancies by targeting the mitotic spindle and cyclins and thus triggering apoptosis.…”

Section: Resultsmentioning

confidence: 99%

Chemical Investigation of a Biologically Active Schinus molle L. Leaf Extract

Garzoli

Masci

Ovidi

et al. 2019

Journal of Analytical Methods in Chemistry

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The pepper tree Schinus molle L. is an evergreen ornamental plant belonging to the Anacardiaceae family, native to South America and widespread throughout the world. It has biological activities and is used in folk medicine. This paper aims to contribute to a deeper knowledge of its chemical composition and biological properties. S. molle leaf extracts were obtained by sequential extraction with solvents of different polarities and subsequently tested on the HL-60 human leukaemia cell line to define a possible cytotoxic activity. Among the investigated extracts, the petroleum ether extract revealed a high cytotoxic activity, and its chemical composition was further investigated. By a silica column chromatography, eight fractions were obtained, and their compositions were determined by GC-MS analysis. Compounds and relative abundance differed widely among the fractions; sesquiterpenes resulted the main component and alcoholic sesquiterpenes the most abundant.

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Section: Resultsmentioning

confidence: 99%

Chemical Investigation of a Biologically Active Schinus molle L. Leaf Extract

Garzoli

Masci

Ovidi

et al. 2019

Journal of Analytical Methods in Chemistry

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“…Ferulenol (2) also exerts anti-cancer activity through the downregulation of Bcl2 protein along with upregulation of Bax protein in benzo[a]pyrene-induced lung cancer in a rat model [ 13 ]. This indicated ferulenol (2) as a pro-oxidant and chemotherapeutic agent and has been recognized as an interesting lead compound for anti-cancer semi-synthesis [ 13 , 14 ]. In searching for the novel anticoagulant warfarin derivatives, ferulenol (2) exhibits higher activity than the warfarin drug (approximately 22 times) with lower toxicity [ 15 , 16 ].…”

Section: Introductionmentioning

confidence: 99%

Synthesis of Ferulenol by Engineered Escherichia coli: Structural Elucidation by Using the In Silico Tools

et al. 2021

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4-Hydroxycoumarin (4HC) has been used as a lead compound for the chemical synthesis of various bioactive substances and drugs. Its prenylated derivatives exhibit potent antibacterial, antitubercular, anticoagulant, and anti-cancer activities. In doing this, E. coli BL21(DE3)pLysS strain was engineered as the in vivo prenylation system to produce the farnesyl derivatives of 4HC by coexpressing the genes encoding Aspergillus terreus aromatic prenyltransferase (AtaPT) and truncated 1-deoxy-D-xylose 5-phosphate synthase of Croton stellatopilosus (CstDXS), where 4HC was the fed precursor. Based on the high-resolution LC-ESI(±)-QTOF-MS/MS with the use of in silico tools (e.g., MetFrag, SIRIUS (version 4.8.2), CSI:FingerID, and CANOPUS), the first major prenylated product (named compound-1) was detected and ultimately elucidated as ferulenol, in which information concerning the correct molecular formula, chemical structure, substructures, and classifications were obtained. The prenylated product (named compound-2) was also detected as the minor product, where this structure proposed to be the isomeric structure of ferulenol formed via the tautomerization. Note that both products were secreted into the culture medium of the recombinant E. coli and could be produced without the external supply of prenyl precursors. The results suggested the potential use of this engineered pathway for synthesizing the farnesylated-4HC derivatives, especially ferulenol.

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“…I have been studying the pharmacotoxicological properties of the medicinal plants of Asia and the Pacific for the last 15 years [2,3,4,5,6,7] and the sole members of the genus Paulownia Siebold & Zucc. (1835) officially recognized in China and Korea are Paulownia catalpifolia T. Gong ex D.Y.…”

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confidence: 99%

Lee et al., Inhibitory Effect and Mechanism of Antiproliferation of Isoatriplicolide Tiglate (PCAC) from Paulownia Coreana. Molecules 2012, 17, 5945-5951: A Note Regarding Paulownia coreana.

Wiart

2013

Molecules

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I read with interest the article by Lee et al. entitled “Inhibitory Effect and Mechanism of Antiproliferation of Isoatriplicolide Tiglate (PCAC) from Paulownia Coreana” [1]. This article is quite interesting and the authors should be complimented for the significant amount of work they have done. The purpose of this letter is to call attention to the need for some clarification on the name of the plant described in this article. Lee et al. state: “Paulownia coreana has traditionally been used as the medicine and health food in the treatment of cancer and infectious diseases.” and elsewhere: “In fact, many cancer research studies have been conducted using traditional medicinal plants such as P. coreana.” [1].

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Terpenes

Cited by 11 publications

References 474 publications

Chemical Investigation of a Biologically Active Schinus molle L. Leaf Extract

Chemical Investigation of a Biologically Active Schinus molle L. Leaf Extract

Synthesis of Ferulenol by Engineered Escherichia coli: Structural Elucidation by Using the In Silico Tools

Lee et al., Inhibitory Effect and Mechanism of Antiproliferation of Isoatriplicolide Tiglate (PCAC) from Paulownia Coreana. Molecules 2012, 17, 5945-5951: A Note Regarding Paulownia coreana.

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