Terpenoids and Flavonoids from <i>Artemisia</i> Species

Tang, Hai Qiu; Hu, Jun; Yang, Li; Tan, Ren Xiang

doi:10.1055/s-2000-8538

Cited by 102 publications

(52 citation statements)

References 4 publications

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“…OA is prevalent in Oleaceae family, especially in olive (O. europaea), the plant species after which the compound was named and that still serves as the main source of commercial OA (Pollier & Goossens, 2012;Sporn et al, 2011). Many pharmacological activities of OA have been reported such as antifungal (Tang et al, 2000), insecticidal (Marquina et al, 2001), anti-HIV (Ma et al, 2000), diuretic (Alvarez et al, 2002), complement inhibitory (Assefa et al, 2001), liver-protection (Yim et al, 2001), anti-inflammatory (Ismaili et al, 2001) and gastrointestinal transit modulating activities (Li et al, 1999). In recent years, it was found that OA exhibited the significant antitumor effect and cytotoxic activity toward many cancer cell lines such as liver cancer cells, colon carcinoma cells and fibrosarcoma cells (Li et al, 2002;Yan et al, 2010).…”

Section: Introductionmentioning

confidence: 99%

Oleanolic acid induces apoptosis of MKN28 cells via AKT and JNK signaling pathways

Zhu

Chen

et al. 2014

Pharmaceutical Biology

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Context: Oleanolic acid (OA) belongs to the triterpenoid compound group existing widely in food, medicinal herbs and other plants. Its effects on gastric cancer cells and the mechanisms involved have not been investigated. Objective: This study aimed to substantiate whether OA induces apoptosis of gastric cancer cell line (MKN28) and to elucidate the molecular mechanism involved. Materials and methods: Cell viability was assessed by MTT assay within the range of 0-160 mg/ mL. The effects of OA (5, 10 and 20 mg/mL) on apoptosis of MKN28 cells were evaluated by flow cytometry, DNA fragmentation and mitochondrial membrane potential assays. Western blot and FQRT-PCR assays were used to investigate the mechanism of cell apoptosis induced by OA (5 and 10 mg/mL). Results: OA evidently inhibited cell viability with IC 50 of 44.8 and 15.9 mg/mL at 12 and 24 h, respectively. Furthermore, OA increased JNK phosphorylation, decreased AKT phosphorylation, but did not affect p38 and ERK phosphorylation in MKN28 cells. In contrast, OA also significantly enhanced the mRNA expression levels of caspase 3, caspase 9 and Apaf-1 in MKN28 cells. Conclusion: OA induces apoptosis of MKN28 cells via the mitochondrial pathway regulated by AKT and JNK signaling pathways.

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Section: Introductionmentioning

confidence: 99%

Oleanolic acid induces apoptosis of MKN28 cells via AKT and JNK signaling pathways

Zhu

Chen

et al. 2014

Pharmaceutical Biology

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“…The Asteraceae is an immense plant family that contains many major ornamental and medicinal plants (Tang et al 2000). The tribe Anthemideae is one of the largest tribes of the family with 1741 species predominantly distributed in Eurasia, North and South Africa, with fewer species in North America and Australia (Bremer and Humphries 1993).…”

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confidence: 99%

Karyomorphological studies of some species of Chrysanthemum sensu lato in Egypt

El-Twab¹,

Mekawy²,

El‐Katatny³

2008

Chromosome Botany

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ABSTRACT. Chromosome numbers and karyotypes are presented in eight taxa in Chrysanhemum senu lato (Asteraceae).Achillea santolina, Cotula barbata and Co. cinerea had new counts for the first time. The chromosome complement of Artemisia arborescens (2n=18) consists of 14 median and four sub-median chromosomes. Achillea fragrantissima (2n=18) consists of 14 median and four sub-median chromosomes; Ach. santolina (2n=36) consists of 26 median-and ten submedian-centromeric chromosomes. Glebionis coronaria (2n=18) consists of 18 median-centromeric chromosomes; while G. coronaria var. discolor (2n= 18) has 16 median-and two submedian-centromeric chromosomes. Cotula barbata (2n=16) consists of 12 median-and four sub-median-centromeric chromosomes, while Co. cinerea (2n=18) has 14 median-and four sub-median-centromeric chromosomes. The chromosome complement of Matricaria recutita (2n=18) consists of 14 median-, two submedian-and two subterminal-centromeric chromosomes.The longest chromosome complement was Artemisia arborescens while the shortest was Cotula barbata. The length of the tetraploid chromosome complement of Ach. santolina was approximately one third shoter than the diploid Artemisia arborescens, and equal to G. coronaria.

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“…These plant compounds, as well as sesquiterpenes from Artemisia sieversiana Ehrh. (Tang et al, 2000), have demonstrated suppressive Ggt growth activity.…”

Section: Discussionmentioning

confidence: 99%

Crude extracts of Drimys winteri bark to inhibit growth of Gaeumannomyces graminis var. tritici

Zapata¹,

Vargas²,

Monsálvez³

et al. 2011

Chilean J. Agric. Res.

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The aim of this study was to assess the effect of Drimys winteri J.R. Forst. & G. Forst. bark and its extracts, obtained sequentially with n-hexane, acetone, and methanol, against Gaeumannomyces graminis var. tritici (Ggt). Ground bark of D. winteri was mixed with potato dextrose agar growth media at concentrations of 250, 500, 1000, 2000, and 4000 mg L -1 in Petri plates. Each extract was mixed at concentrations of 100, 200, 400, and 800 mg L -1 . Petri plates were inoculated in the center with a 5-mm mycelium disk and were incubated at 24 ± 1 ºC. Daily measurements of mycelium radial growth were taken to determine growth rate and growth inhibition (%). A ground bark concentration of 978 mg L -1 was needed to inhibit Ggt growth by 50%, while extracts obtained with n-hexane and acetone only required 198 and 234 mg L -1 , respectively. The methanol extract only inhibited Ggt growth by 33% when tested at the highest concentration. In conclusion, ground bark and crude extracts, obtained sequentially with n-hexane, acetone, and methanol, from D. winteri bark inhibit Ggt growth when applied in vitro. The n-hexane extract showed the highest inhibitory growth activity.

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Terpenoids and Flavonoids from Artemisia Species

Cited by 102 publications

References 4 publications

Oleanolic acid induces apoptosis of MKN28 cells via AKT and JNK signaling pathways

Oleanolic acid induces apoptosis of MKN28 cells via AKT and JNK signaling pathways

Karyomorphological studies of some species of Chrysanthemum sensu lato in Egypt

Crude extracts of Drimys winteri bark to inhibit growth of Gaeumannomyces graminis var. tritici

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