Terpenoids and Phenylpropanoids Isolated from the Twigs and Leaves of Abelia macrotera and Their Anti‐Inflammatory Activities

Abstract

A new triterpenoid, 3β‐hydroxyurs‐12‐en‐28,20β‐olide (1), as well as thirteen known terpenoids (2–14) and three known phenylpropanoids (15–17), were isolated from the twigs and leaves of Abelia macrotera. Compounds 2, 5–17 were isolated for the first time from the Abelia genus. The structure of compound 1 was determined using the characteristic spectral data (HR‐ESI‐MS, UV, 1D and 2D‐NMR, and X‐ray single‐crystal diffraction. Furthermore, the inhibitory effects of all compounds on NO production in LPS‐induced RAW 264.7 cells were tested, and compound 15 showed obvious inhibitory effect, with IC50 values of 23.77±1.61 μM. Through target screening and molecular docking technology, it can be speculated that compound 15 may play an anti‐inflammatory role by combining with Cathepsin G & Chymase and HPG D.

Evaluation of Caralluma edulis for its Potential Against Obesity, Atherosclerosis and Hypertension

“… 43 The presence of phytochemical compounds in CE.Cr including terpenoids, phenyl propanoids, and iridoids have been reported for their antioxidant activity which might be linked to the anti-hyperlipidemic effects. 44 …”

“…43 The presence of phytochemical compounds in CE.Cr including terpenoids, phenyl propanoids, and iridoids have been reported for their antioxidant activity which might be linked to the antihyperlipidemic effects. 44 Reverse cholesterol transport, a mechanism in which excess tissue cholesterol is taken up and processed by HDL particles before being sent to the liver for metabolism, is largely responsible for maintaining cholesterol levels in the body. As a result, an increase in HDL levels lowers the risk of atherosclerosis.…”