Terpenoids and Sterols from Mushrooms

Yaoita, Yasunori; Kikuchi, Masao; Machida, Koichi

doi:10.1016/b978-0-444-63460-3.00001-8

Cited by 13 publications

(8 citation statements)

References 112 publications

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“…On the other hand, despite there being numerous reports on the biological activities of the natural lanostane-type triterpenoids like inhibit tumor cell growth, induce apoptosis, and inhibit angiogenesis and metastasis [ 20 , 21 ], these compounds did not have cytotoxic activity in all 6 cell lines. However, there was cell growth inhibition illustrated by five cell lines including L929, A431, A549, PC-3, and MCF-7 with later showing most cell growth inhibited by both compounds.…”

Section: Resultsmentioning

confidence: 99%

Two New Triterpenes from Basidiomata of the Medicinal and Edible Mushroom, Laetiporus sulphureus

2021

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In the search for novel anti-infectives from natural sources, fungi, in particular basidiomycetes, have proven to still harbor so much potential in terms of secondary metabolites diversity. There have been numerous reports on isolating numerous secondary metabolites from genus Laetiporus. This study reports on two new triterpenoids, laetiporins C and D, and four known triterpenes from the fruiting body of L. sulphureus. The structures of the isolated compounds were elucidated based on their 1D and 2D nuclear magnetic resonance (NMR) spectroscopic data in combination with high-resolution electrospray mass spectrometric (HR-ESIMS) data. Laetiporin C exhibited weak antifungal activity against Mucor hiemalis. Furthermore, the compounds showed weak antiproliferative activity against the mouse fibroblast L929 and human cancer cell lines, including KB-3-1, A431, MCF-7, PC-3 and A549.

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Section: Resultsmentioning

confidence: 99%

Two New Triterpenes from Basidiomata of the Medicinal and Edible Mushroom, Laetiporus sulphureus

2021

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“…Steroids are essential eukaryotic constituents, are secondary metabolites of mushroom metabolism and are biosynthesized through triterpenoids [157]. According to Rangsinth et al and Baker et al [159,160], the main sterol in mushrooms is ergosterol.…”

Section: Sterols From Mushroomsmentioning

confidence: 99%

Bioactive Compounds Produced by Macromycetes for Application in the Pharmaceutical Sector: Patents and Products

Martinez-Burgos,

Montes Montes,

Pozzan

et al. 2024

Fermentation

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It is widely known that mushrooms present several properties with applications in the medicinal and pharmaceutical sectors, including antimicrobial, immunomodulatory, antioxidant, hypotensive, neuroprotective, and anti-inflammatory activities. This article aims to review examples of the bioactive metabolites responsible for those activities, such as polysaccharides, phenols and polyphenols, terpenes, peptides, alkaloids, and steroids, which are produced by several relevant mushroom species. It also discusses their production through solid-state fermentation and submerged fermentation, as well as the processes of obtention of mushroom bioactive extracts and considerations on their stability aiming industrial applications. In addition, the article examines the patent landscape surrounding mushroom-derived bioactives, shedding light on the intellectual property history and innovations driving this field forward. Examples of recently deposited patents in the field are highlighted, as well as the main depositors. China and the United States are the major depositor countries in this field (52% and 35% of patents, respectively), and the principal compounds on the patents are polysaccharides and alkaloids. The article also provides insights into the current market landscape, showcasing mushroom-derived products in the pharmaceutical field available to consumers. From dietary supplements to skincare formulations, the market offerings reflect the growing interest in harnessing the health benefits of mushroom bioactives.

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“…Terpenoids (terpenes and oxygenated derivatives) constitute one of the largest groups of naturally occurring compounds, which are characterized by their very wide distribution in both the plant and animal kingdoms and have also recently been obtained from endophytic fungi [ 62 , 63 , 64 ]. A terpenoid derivative, namely meroterpenoid, is a compound that is formed from a combination of frameworks between terpenoid and polyketide frameworks, alkaloids, phenols, and amino acids [ 65 , 66 , 67 , 68 ]. It can be obtained by bacteria, algae, plants, and animals, as well as endophytic fungi, one of the endophytic fungi producing meroterpenoid compounds, namely Biscogniauxia sp.…”

Section: Secondary Metabolitesmentioning

confidence: 99%

Secondary Metabolites of Biscogniauxia: Distribution, Chemical Diversity, Bioactivity, and Implications of the Occurrence

Purbaya,

Harneti,

Safriansyah

et al. 2023

Toxins

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The genus Biscogniauxia, a member of the family Xylariaceae, is distributed worldwide with more than 50 recognized taxa. Biscogniauxia species is known as a plant pathogen, typically acting as a parasite on tree bark, although certain members of this genus also function as endophytic microorganisms. Biscogniauxia endophytic strain has received attention in many cases, which includes constituent research leading to the discovery of various bioactive secondary metabolites. Currently, there are a total of 115 chemical compounds belonging to the class of secondary metabolites, and among these compounds, fatty acids have been identified. In addition, the strong pharmacological agents of this genus are (3aS,4aR,8aS,9aR)-3a-hydroxy-8a-methyl-3,5-dimethylenedecahydronaphto [2,3-b]furan-2(3H)-one (HDFO) (antifungal), biscopyran (phytotoxic activity), reticulol (antioxidant), biscogniazaphilone A and B (antimycobacterial), and biscogniauxone (Enzyme GSK3 inhibitor). This comprehensive research contributes significantly to the potential discovery of novel drugs produced by Biscogniauxia and holds promise for future development. Importantly, it represents the first-ever review of natural products originating from the Biscogniauxia genus.

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Terpenoids and Sterols from Mushrooms

Cited by 13 publications

References 112 publications

Two New Triterpenes from Basidiomata of the Medicinal and Edible Mushroom, Laetiporus sulphureus

Two New Triterpenes from Basidiomata of the Medicinal and Edible Mushroom, Laetiporus sulphureus

Bioactive Compounds Produced by Macromycetes for Application in the Pharmaceutical Sector: Patents and Products

Secondary Metabolites of Biscogniauxia: Distribution, Chemical Diversity, Bioactivity, and Implications of the Occurrence

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