Terpenoids from Elsholtzia Species; II. Constituents of Essential Oil from a New Chemotype of<i>Elsholtzia cristata</i>

This study reports on the optimization of a microwave-assisted distillation process to obtain Dong Van marjoram essential oil, and the determination of its composition, content of constituents, and cytotoxic and antimicrobial activities. Using the response surface method (RSM), the optimal essential oil distillation conditions were determined as material size 0.74 (cm), water to material ratio 4.14:1 (mL/g), microwave power 302.4 (W), and distillation time 2.1 hours. At optimal conditions, the mass of Dong Van marjoram essential oil obtained was 0.887 ± 0.007 g, corresponding to a content of 0.6% essential oil in the material. GC-MS and GC-FID methods showed that the main chemical constituents of Dong Van marjoram essential oils obtained were rosefuran epoxide (44.9%), caryophyllene (10.8%), germacrene D (2.6%), and α-humulene (1.3%). The essential oil exhibited moderate inhibition against both tested cancer cell lines, with IC50 values of 23.9 µg/mL (for PC3) and 56.2 µg/mL (for A549). However, the oil exhibited strong effectiveness against three bacterial strains, Escherichia coli, Bacillus subtilis, and Staphylococcus aureus, and a yeast strain, Saccharomyces cerevisiae, with minimal inhibitory concentration (MIC) values ranged from 50 to 100 µg/mL.

show abstract

“…contained 23 components with the major one being 3-methyl-2-(3-methylbut-2-enoyl)-furan, accounting for up to 88.7%. 23…”

Section: Resultsmentioning

confidence: 99%

“…contained 23 components with the major one being 3-methyl-2-(3-methylbut-2-enoyl)-furan, accounting for up to 88.7%. 23 The results of this study have contributed to clarifying the chemical composition of the essential oil of marjoram dong van from Ha Giang province, Vietnam.…”

Section: Chemical Composition Of the Oilsmentioning

confidence: 85%

Optimization of the Essential Oil Extraction Process from Dong Van Marjoram (E. winitiana var. dongvanensis Phuong.) by Using Microwave Assisted Hydrodistillation, and the Bioactivities of the Oil Against Some Cancer Cell Lines and Bacteria

Thị

Cam

et al. 2021

Natural Product Communications

View full text Add to dashboard Cite

show abstract

“…The species is native to Asia and is an annual herb, reaching 40–60 cm in height with pilose, green, square stems; crenate‐serrate, ovate to elliptic‐lanceolate leaves and purplish flowers, located on spikes, blooming from July to October [16] . Phytochemical investigations revealed the composition of its essential oil, [17–27] but also the presence of flavonoids, [18,26,28] phenolic acids, [18] steroids and triterpenes, [15,29] of which phenolics are the most abundant non‐volatile compound class [18] . The pharmacological data mentioned in literature, including anti‐acetylcholinesterase activity, [28] anti‐oxidative properties, [30–32] antibacterial, [22,30] vasorelaxant, [18] anti‐leishmanial, [27] cytotoxic, [19] anti‐inflammatory, [32–34] and insecticidal activities [21] mainly refer to total extracts [30,31,33,34] and/or the essential oil [18,19,22,27] .…”

Section: Introductionmentioning

confidence: 99%

Effect of Non‐Volatile Constituents of Elsholtzia ciliata (Thunb.) Hyl. from Southern Vietnam on Reactive Oxygen Species and Nitric Oxide Release in Macrophages

Nguyen

Hung

Schwaiger

et al. 2020

Chemistry & Biodiversity

View full text Add to dashboard Cite

The extract of Elsholtzia ciliata aerial parts was subjected to bio-guided isolation using the intercellular ROS reduction in J774A.1 macrophages to monitor the anti-oxidative activity. Fifteen compounds were isolated from the active fractions including eleven flavonoids (vitexin, pedalin, luteolin-7-O-β-D-glucopyranoside, apigenin-5-Oβ-D-glucopyranoside, apigenin-7-O-β-D-glucopyranoside, chrysoeriol-7-O-β-D-glucopyranoside, 7,3'-dimethoxyluteolin-6-O-β-D-glucopyranoside, luteolin, 5,6,4'-trihydroxy-7,3'-dimethoxyflavone, 5-hydroxy-6,7-dimethoxyflavone (compound 13), 5-hydroxy-7,8-dimethoxyflavone); three hydroxycinnamic acid derivatives (caffeic acid, 4-(E)-caffeoyl-L-threonic acid, 4-O-(E)-p-coumaroyl-L-threonic acid) and one fatty acid (α-linolenic acid). The biological evaluation of these compounds (10-2.5 μM) indicated that all of them exerted good antioxidant and anti-inflammatory activities, in particular compound 13.

show abstract

Chemical Diversity in Himalayan Elsholtzia Species

Mathela

Padalia

Joshi

et al. 2009

Chemistry & Biodiversity

View full text Add to dashboard Cite

The terpenoid composition of essential oils from the leaves of five Elsholtzia species, viz., E. eriostachya Benth., E. cristata Willd., E. polystachya Benth., E. flava Benth., and E. pilosa Benth., collected from the Himalayan region (India), was examined by GC, GC/MS, and NMR analyses. Comparison of the results with previous reports revealed new chemotypes. Cluster analysis was carried out in order to discern the similarities and differences within the essential-oil compositions at their subspecies/chemotype level. Based on the major constituents of the essential oils, six chemical groups were obtained.

show abstract

Terpenoids from Elsholtzia Species; II. Constituents of Essential Oil from a New Chemotype ofElsholtzia cristata

Cited by 13 publications

References 5 publications

Optimization of the Essential Oil Extraction Process from Dong Van Marjoram (E. winitiana var. dongvanensis Phuong.) by Using Microwave Assisted Hydrodistillation, and the Bioactivities of the Oil Against Some Cancer Cell Lines and Bacteria

Optimization of the Essential Oil Extraction Process from Dong Van Marjoram (E. winitiana var. dongvanensis Phuong.) by Using Microwave Assisted Hydrodistillation, and the Bioactivities of the Oil Against Some Cancer Cell Lines and Bacteria

Effect of Non‐Volatile Constituents of Elsholtzia ciliata (Thunb.) Hyl. from Southern Vietnam on Reactive Oxygen Species and Nitric Oxide Release in Macrophages

Chemical Diversity in Himalayan Elsholtzia Species

Contact Info

Product

Resources

About