Terpenoids from Euphorbia helioscopia and Their Cytotoxic Activities against H1975 Cells

Abstract

Three previously undescribed diterpenoids, helioscopnoids A–C, and eight known compounds were isolated from the whole plants of Euphorbia helioscopia. Their structures were established by extensive analysis of spectra and data comparison with previous literatures. Among them, compound 4 was identified as 24,24‐dimethoxy‐25,26,27‐trinoreuphan‐3β‐ol with revised configurations of C‐13, C‐14, and C‐17 (13R*, 14R*, 17R*). Cytotoxicity assays revealed that all compounds exhibited varying levels of cytotoxicity against H1975 cells, with compound 9 displaying the most potent activity, as indicated by cell viability rates of 18.13 % and 20.76 % at concentrations of 20 μM and 5 μM, respectively. This study expands the understanding of E. helioscopia terpenoids’ structural diversity and biological activities, contributing to the exploration of potential therapeutic applications.

Quassinoids from Twigs of Harrisonia perforata (Blanco) Merr and Their Anti-Parkinson’s Disease Effect

“…For example, harpertrioate A reduced Aβ42 and Aβ40 production and shifted APP processing toward a nonamyloidogenic pathway, while perforalactones D and E significantly induced lysosomal biogenesis through transcriptional activation of lysosomal genes [6,22]. As part of our ongoing work to discover [23] bioactive molecules from plant [14,20,21,[24][25][26][27], we isolated seven undescribed quassinoids (1)(2)(3)(4)(5)(6)(7), including six C-20 and one C-19 quassinoids from the twigs of this plant. We also verified the oxidative degradation of C-25 quassinoid, perforalactone B (Figure 1), to the C-20 quassinoid, perforaquassin A, through chemical transformation, and then the crucial "link" between C-25 type and C-20 type quassinoids was proposed.…”