Terpenoids from the Roots of Stellera chamaejasme (L.) and Their Bioactivities

Abstract

An undescribed diterpene, stellerterpenoid A (1), and two undescribed sesquiterpenoids, stellerterpenoids B and C (2–3), together with six known compounds, prostratin (4) stelleraguaianone B (5), chamaejasnoid A (6), auranticanol L (7), wikstronone C (8), and oleodaphnone (9), were isolated from the roots of Stellera chamaejasme L. Their structures were elucidated by extensive spectroscopic data (1D, 2D NMR, IR, UV, and HR-ESI-MS). The absolute configuration of 1–3 was elucidated based on ECD calculation. Among them, stellerterpenoid A was a rare 13, 14-seco nortigliane diterpenoid and stellerterpenoid B was a guaiacane-type sesquiterpenoid with an unusual 1, 2-diketone moiety. The known stelleraguaianone B (5) exhibited moderate activity for suppressing NO production in lipopolysaccharide (LPS)-treated RAW 264.7 macrophages cells with an IC50 value of 24.76 ± 0.4 μM. None of the compounds showed anti-influenza virus or anti-tumor activity in vitro.

High-throughput sequencing-based analysis of the composition and diversity of the endophyte community in roots of Stellera chamaejasme

“…At present, research on S. chamaejasme mainly focuses on morphology 27 , ecology 28 , chemicals 29 and biological control 30 . When S. chamaejasme is used for medicinal purposes, the main part used is its root, and a large number of studies on its medicinal ingredients have mainly focused on the root 31 , 32 . At the same time, roots are also important organs of plants, not only able to absorb nutrients from the soil, but also play a vital role in improving the survival of plants under various external environmental conditions 33 .…”