Terpenoids from Vitex trifolia and their anti-inflammatory activities

Bao, Fengyan; Tang, Ruotian; Li, Cheng; Zhang, Cuiyun; Qiu, Chongyue; Yuan, Ting; Zhu, Lihan; Li, Hua; Chen, Lixia

doi:10.1007/s11418-018-1178-x

Cited by 16 publications

(9 citation statements)

References 19 publications

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“…Furthermore, a new iridoid glycoside was found in V . trifolia L. producing (1 S , 5 S ,6 R ,9 R )-10- O - p -hydroxybenzoyl-5,6 β -dihydroxy iridoid 1- O - β -D-glucopyranosidem ( 22 ) [ 82 ]. The isolated compound 22 was assessed for NO inhibitory activity tested on LPS-induced murine macrophage (RAW 264.7) cells to exhibit moderate inhibitory activity with an IC 50 value of 90.05 μM.…”

Section: Secondary Metabolites Isolated From Vitex ...mentioning

confidence: 99%

Traditional Medicinal Uses, Phytochemistry, Biological Properties, and Health Applications of Vitex sp.

Kamal

Asni

Rozlan

et al. 2022

Plants

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The genus Vitex is also known as a chaste tree, in which it is a large shrub native to the tropical and subtropical regions of the world. A diverse range of species is distributed throughout Southern Europe, the Mediterranean, and Central Asia. The Vitex tree, including its leaves and fruits, has been used for herbal remedies in the form of pastes, decoctions, and dried fruits since ancient times. This article aimed to prepare a comprehensive review of traditional uses and secondary metabolites derived from Vitex sp., including the chemical compounds, biological activities, application of Vitex in human clinical trials, toxicology and safety, marketed products, and patents. The scientific findings were obtained using a number of search engines and databases, including Google Scholar, PMC, and ScienceDirect. Vitex species are well known in pharmacology to have medicinal values, such as anti-inflammatory, antibacterial, antifungal, antimicrobial, antioxidant, and anticancer properties. Previous studies reported that some species are proven to be effective in treating diseases, such as diabetes, and improving female health. A total of 161 compounds from different Vitex species are reported, covering the literature from 1982 to 2022. A chemical analysis report of various studies identified that Vitex exhibited a wide range of phytoconstituents, such as iridoid, diterpenoid, ecdysteroid, and flavonoid and phenolic compounds. Apart from that, the review will also discuss the application of Vitex in human clinical trials, toxicology and safety, marketed products, and patents of the genus. While the extracts of the genus have been made into many commercial products, including supplements and essential oils, most of them are made to be used by women to improve menstrual conditions and relieve premenstrual syndrome. Among the species, Vitex agnus-castus L. is the only one that has been reported to undergo clinical trials, mainly related to the use of the genus for the treatment of mastalgia, menstrual bleeding problems, amenorrhea, menorrhagia, luteal insufficiency, and premenstrual syndrome. Overall, the review addresses recent therapeutic breakthroughs and identifies research gaps that should be explored for prospective research work.

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Section: Secondary Metabolites Isolated From Vitex ...mentioning

confidence: 99%

Traditional Medicinal Uses, Phytochemistry, Biological Properties, and Health Applications of Vitex sp.

Kamal

Asni

Rozlan

et al. 2022

Plants

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“…Based on this, developing environmentally friendly incense organic raw materials such as Legundi leaf (Vitex trifolia L.), lemongrass leaves (Andropogon nardus), and wood grain packaged in Legiayu incense, are necessary The pharmacologically content of oleum citronellal, geraniol, tannin, flavonoids, saponins, champine, pinine and polyphenols that serve as insecticides and larvicide (Bao et al, 2018;Chan et al, 2016). These compound has benefits as contact, stomach and respiratory toxins that result in death (Susilowati et al, 2018).…”

Section: Introductionmentioning

confidence: 99%

“…Flavonoid and tannin are able to provide toxic effects that are able to clump the protein of Aedes aegypti larvae. Flavonoid compounds are able to regulate proteins that result in the permeability of the cell walls of larvae decreased which has an impact on the loss of excitatory stimulus of eating and larvae experience death (Bao et al, 2018;Siew et al, 2019).…”

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confidence: 99%

Toxicity of Legiayu incense as Insecticide and Larvicide Against Aedes aegypti Mosquitoes Mortality

2021

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Community-based DHF vector control has been implemented in Indonesia but has not yet obtained optimal results. Thus, in the community choosing synthetic insecticides to control disease vectors. However, irregular and excessive use of insecticides has a toxic effect and resistance to mosquitoes. Burning mosquito coils and incense containing synthetic dyes and fragrances have the potential to reduce environmental quality. Therefore, this research was conducted to analyze the toxicity of Legiayu incense as an insecticide and larvicide against Aedes aegypti mosquito mortality. The research design is experimental with a completely randomized design. Testing was conducted by providing exposure to smoke and ash of Legiayu incense five times on twenty-five Aedes aegypti mosquitoes. Statistical analysis used one-way ANOVA, LSD, and probit test. The test result as insecticide value (p=0.000) effective exposure for 20 minutes with a durability of 6 hours. The test result as larvicide value (p=0.000) effective exposure for 24 hours. Thus, exposure toismoke and ash of iLegiayuiincense has a very noticeable effect on the mortality of Aedes aegypti mosquitoes. Exposureito Legiayu incense smoke obtained an LT50 value of 0,9012 ≤ 5 (super toxic category) with a time of 15 minutes 39 seconds, coefficient determination of 99.24%, and correlation coefficient of 99.62% while exposure to the ash of Legiayu incense obtained LT50 value of 0,05896 ≤ 5 (super toxic category) with time 19 hours 15 minutes 34 seconds, coefficient determination and correlation coefficient of 100%. Histopathological test results showed that Legiayu incense smoke did not cause tissue degeneration, necrosis, hyperplasia, and metaplasia in the lung tissue of mice (mus musculus) within a period of 12 weeks. Thus, Legiayu incense is effective as insecticides and larvicides against Aedes aegypti mosquitoes. Legiayu incense has potential substitute for mosquito repellent coils, temephos, and synthetic incense circulating in the market.

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“…In Japan, VTF has been taken as a natural analgesic (Oshima et al, 2016). Moreover, recent research has indicated the extensive biological activities of VTF including antitumor (Cao et al, 2016; Haïdara, Zamir, Shi, & Batist, 2006; Kobayakawa, Satonishimori, Moriyasu, & Matsukawa, 2004), antinociceptive, antihyperprolactinemia (Hu et al, 2007), antifibrosis (Zhou et al, 2017), antiinflammation (Bao et al, 2018; Lee, Jung, Ji, & Bae, 2017), antiasthma (Park et al, 2014) as well as the rosiglitazone‐like effects (Nishina et al, 2017). However, the mixing and misuse of other species with VTF were found during the formulation and application, including two congeneric species of VTF namely Vitex cannabifolia fruit (VCF) and Vitex negundo fruit (VNF) (Zhang et al, 2019) along with three adulterant species including Piper cubeba fruit (PCF) (Fam.…”

Section: Introductionmentioning

confidence: 99%

Comprehensive identification of Vitex trifolia fruit and its five adulterants by comparison of micromorphological, microscopic characteristics, and chemical profiles

Wang

Liu

et al. 2020

Microscopy Res & Technique

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Prevention against the adulteration of traditional Chinese medicine in an accurate way has been long exploring. Vitex trifolia fruit (VTF), as a widely used analgesic in East Asia, has frequently been found to be adulterated with five adulterants, namely Vitex cannabifolia fruit (VCF) (Fam. Verbenaceae), Vitex negundo fruit (VNF) (Fam. Verbenaceae), Piper cubeba fruit (PCF) (Fam. Lauraceae), Euphorbia lathyris seed (ELS) (Fam. Euphorbiaceae), and Vaccinium bracteatum fruit (VBF) (Fam. Ericaceae). In this study, the methods of micromorphological identification, microscopic identification, and chemical analysis were combined to distinguish VTF from its five adulterants comprehensively. As a result, the micromorphological features in terms of fruit or seed epidermis were photographed by stereomicroscopy firstly. Secondly, the microscopic characteristics of various herb powders were captured under light microscopy. Thirdly, 33 nonvolatile components and 124 volatile components in VTF were identified by ultra-performance liquid chromatography coupled with Orbitrap mass spectrometry (UPLC-Orbitrap-MS) and comprehensive two-dimensional gas chromatography hyphenated with mass spectrometry (GC × GC-MS), respectively. Furthermore, betulinic acid, persicogenin, and the volatile 4-(2,2,6-trimethyl-bicyclo [4.1.0]hept-1-yl)-butan-2-one were screened out to be the specific markers of VTF distinctive from the adulterants. Collectively, VTF and its five adulterants were distinguished successfully by the comparison of micromorphological, microscopic characteristics, and chemical profiles.

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Terpenoids from Vitex trifolia and their anti-inflammatory activities

Cited by 16 publications

References 19 publications

Traditional Medicinal Uses, Phytochemistry, Biological Properties, and Health Applications of Vitex sp.

Traditional Medicinal Uses, Phytochemistry, Biological Properties, and Health Applications of Vitex sp.

Toxicity of Legiayu incense as Insecticide and Larvicide Against Aedes aegypti Mosquitoes Mortality

Comprehensive identification of Vitex trifolia fruit and its five adulterants by comparison of micromorphological, microscopic characteristics, and chemical profiles

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