Terpenoids. VIII.<sup>1</sup> The Structures of the Cactus Triterpenes Gummosogenin and Longispinogenin<sup>2,3</sup>

Djerassi, Carl; Geller, Leo; Lemin, A. J.

doi:10.1021/ja01645a009

Cited by 30 publications

(3 citation statements)

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“…Both of the hosts used in this study (agria and organpipe) are columnar cacti and therefore have some common features. While both agria and organpipe contain very low concentrations of free sugars and large amounts of lipids and triterpene glycosides (Kircher 1982), they differ considerably in which classes of lipids and triterpene glycoside they contain (Djerassi et al 1954;Djerassi & Lippman 1955;Kircher 1982). For example, the agria cactus contains specific triterpenes (possible saponins) which were used by native people to poison fish (Bravo-Hollis 1978).…”

Section: Metabolic Response To Cactus Host Shiftsmentioning

confidence: 99%

Functional genomics of cactus host shifts in Drosophila mojavensis

et al. 2006

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Understanding the genetic basis of adaptation to novel environments remains one of the major challenges confronting evolutionary biologists. While newly developed genomic approaches hold considerable promise for addressing this overall question, the relevant tools have not often been available in the most ecologically interesting organisms. Our study organism, Drosophila mojavensis, is a cactophilic Sonoran Desert endemic utilizing four different cactus hosts across its geographical range. Its well-known ecology makes it an attractive system in which to study the evolution of gene expression during adaptation. As a cactophile, D. mojavensis oviposits in the necrotic tissues of cacti, therefore exposing larvae and even adults to the varied and toxic compounds of rotting cacti. We have developed a cDNA microarray of D. mojavensis to examine gene expression associated with cactus host use. Using a population from the Baja California population we examined gene expression differences of third instar larvae when reared in two chemically distinct cactus hosts, agria (Stenocereus gummosus, native host) vs. organpipe (Stenocereus thurberi, alternative host). We have observed differential gene expression associated with cactus host use in genes involved in metabolism and detoxification.

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Section: Metabolic Response To Cactus Host Shiftsmentioning

confidence: 99%

Functional genomics of cactus host shifts in Drosophila mojavensis

et al. 2006

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“…Norethindrone was first orally highly active progestin synthesized accidentally by Chemists Carl Djerassi, Luis Miramontes, and George Rosenkranz in 1951 42 . Later, its ability to powerfully disrupt ovulation was recognized, and more importantly, it was found to be effective when taken orally.…”

Section: Norethindronementioning

confidence: 99%

Role of Serendipity in Drug Discovery

Siddiqui¹,

Sharma²,

Sharma³

et al. 2010

Journal of Pharmaceutical Research

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Serendipity, in various shades of semantic legitimacy, is abundantly evident in history of drug discovery. In the present era, although new concept of rational drug design has been introduced even then, lots of drugs have arisen, and continue to arise, from chance observation and correct scientific methods. Chance does not produce drugs; but where chances have played a pivotal role in drug discovery, the event may be considered as serendipitous.

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“…Kurodainol (1) 4 ) The UV, MS, IR, IH and 13C NMR spectra, coupled with spin-decoupling experiments S ) on the 1 H NMR spectrum of 1, indicated the presence of the following structural units: CH 3 -C(X), X-CH 2 -x 2, X-CH~ , -CH2-C(OH)~ ,X-CH = C-CHz-, Br x 3, and Cl x 2. Since combination of these structural units still allowed us to propose more than a few possible formulas for 1, the structure was elucidated by X-ray crystallography.…”

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Structural Elucidation of Kurodainol, a Novel Halogenated Monoterpene from Sea Hare (Aplysia Kurodai)

Masuda¹,

Ina²,

Nozaki³

et al. 1982

Agricultural and Biological Chemistry

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Terpenoids. VIII.¹ The Structures of the Cactus Triterpenes Gummosogenin and Longispinogenin^2,3

Cited by 30 publications

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Functional genomics of cactus host shifts in Drosophila mojavensis

Functional genomics of cactus host shifts in Drosophila mojavensis

Role of Serendipity in Drug Discovery

Structural Elucidation of Kurodainol, a Novel Halogenated Monoterpene from Sea Hare (Aplysia Kurodai)

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Terpenoids. VIII.1 The Structures of the Cactus Triterpenes Gummosogenin and Longispinogenin2,3

Cited by 30 publications

References 0 publications

Functional genomics of cactus host shifts in Drosophila mojavensis

Functional genomics of cactus host shifts in Drosophila mojavensis

Role of Serendipity in Drug Discovery

Structural Elucidation of Kurodainol, a Novel Halogenated Monoterpene from Sea Hare (Aplysia Kurodai)

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Terpenoids. VIII.¹ The Structures of the Cactus Triterpenes Gummosogenin and Longispinogenin^2,3