Terphenylquinone Inhibitors of the Src Protein Tyrosine Kinase from<i>Stilbella</i>sp.

Puder, Carsten; Wagner, Karl G.; Vettermann, Regine; Hauptmann, Rudolf; Potterat, Olivier

doi:10.1021/np040150d

Cited by 35 publications

(23 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Further interest for the anilate ligands is related to their ability to form 3D structures with the (10,3)-a topology, similar to the one observed with the oxalate [111]; these structures are afforded when all the ML 3 units show the same chirality, in contrast with the 2D honeycomb layer, which requires alternating Λ-ML 3 and ∆-ML 3 units. This 3D structure with a (10,3)-a topology has been recently reported for the [(n-Bu) 4 3 ] − type, would afford ferrimagnetic coupling and ordering. Furthermore, if the magnetic coupling depends on the X substituents on the ligand, as expected, a change of X is expected to modify the magnetic coupling and the T c .…”

Section: Introductionsupporting

confidence: 69%

“…Two new isostructural mononuclear complexes of formula [(Ph) 4 (2) have been obtained by reacting the hydranilate anion with the Fe(III) and Cr(III) paramagnetic metal ions [116]. The crystal structure of 1 consists of homoleptic tris-chelated octahedral complex anions [Fe(H 2 An) 3 ] 3− surrounded by crystallization water molecules and (Ph) 4 P + cations.…”

Section: Molecular Paramagnetsmentioning

confidence: 99%

“…Their most appealing technological applications will be also reported. [4], etc. Structural modifications of the natural products afforded related compounds of relevant interest in medicinal chemistry [5,6].…”

Section: General Introductionmentioning

confidence: 99%

“…A breakthrough in this area is represented by the preparation in 1992 by Okawa et al [72] of the family of layered bimetallic magnets based on the oxalate (C 2 O 4 2− ) ligand, formulated as [(n-Bu) 4 N]M II Cr(C 2 O 4 ) 3 ] (M II = Mn, Fe, Co, Ni and Cu) showing the well-known 2D hexagonal honeycomb structure [73,74]. These systems show ferromagnetic order (M III = Cr) with ordering temperatures ranging from 6 to 14 K, or ferrimagnetic order (M III = Fe) with T c ranging from 19 to 48 K [75][76][77][78][79].…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Recent Advances on Anilato-Based Molecular Materials with Magnetic and/or Conducting Properties

et al. 2017

View full text Add to dashboard Cite

Abstract:The aim of the present work is to highlight the unique role of anilato-ligands, derivatives of the 2,5-dioxy-1,4-benzoquinone framework containing various substituents at the 3 and 6 positions (X = H, Cl, Br, I, CN, etc.), in engineering a great variety of new materials showing peculiar magnetic and/or conducting properties. Homoleptic anilato-based molecular building blocks and related materials will be discussed. Selected examples of such materials, spanning from graphene-related layered magnetic materials to intercalated supramolecular arrays, ferromagnetic 3D monometallic lanthanoid assemblies, multifunctional materials with coexistence of magnetic/conducting properties and/or chirality and multifunctional metal-organic frameworks (MOFs) will be discussed herein. The influence of (i) the electronic nature of the X substituents and (ii) intermolecular interactions i.e., H-Bonding, Halogen-Bonding, π-π stacking and dipolar interactions, on the physical properties of the resulting material will be also highlighted. A combined structural/physical properties analysis will be reported to provide an effective tool for designing novel anilate-based supramolecular architectures showing improved and/or novel physical properties. The role of the molecular approach in this context is pointed out as well, since it enables the chemical design of the molecular building blocks being suitable for self-assembly to form supramolecular structures with the desired interactions and physical properties.Keywords: benzoquinone derivatives; molecular magnetism; multifunctional molecular materials; spin-crossover materials; metal-organic frameworks General IntroductionThe aim of the present work is to highlight the key role of anilates in engineering new materials with new or improved magnetic and/or conducting properties and new technological applications. Only homoleptic anilato-based molecular building blocks and related materials will be discussed. Selected examples of para-/ferri-/ferro-magnetic, spin-crossover and conducting/magnetic multifunctional materials and MOFs based on transition metal complexes of anilato-derivatives, on varying the substituents at the 3,6 positions of the anilato moiety, will be discussed herein, whose structural features or physical properties are peculiar and/or unusual with respect to analogous compounds reported in the literature up to now. Their most appealing technological applications will be also reported.

show abstract

Section: Introductionsupporting

confidence: 69%

Section: Molecular Paramagnetsmentioning

confidence: 99%

Section: General Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Recent Advances on Anilato-Based Molecular Materials with Magnetic and/or Conducting Properties

et al. 2017

View full text Add to dashboard Cite

show abstract

“…is shown in Fig. 6 as an example [14]. The four compounds could be obtained in a spectroscopically pure form in a single step.…”

Section: On-line Accurate Mass Measurements and Database Searchmentioning

confidence: 99%

Targeted Approaches in Natural Product Lead Discovery

Potterat¹

2006

Chimia

Self Cite

View full text Add to dashboard Cite

Natural products still constitute a prolific source of lead compounds for the development of novel drugs. Due to their unmatched structural diversity they represent an indispensable complement to synthetic compound collections and virtual libraries. However, the tremendous changes which have taken place in the drug discovery process over the last decade have introduced completely new requirements for natural product research. The classical bioactivity-guided approach no longer matches the timelines and the workflow of modern drug discovery. More targeted approaches are needed in order to identify promising candidate molecules at an early stage, and to accelerate the follow-up process. We describe herein our strategy for tracking bioactive components in complex mixtures, and discuss the potential of accurate mass measurements for natural product identification and the impact of mass-controlled preparative HPLC on the isolation process of bioactive compounds.

show abstract

Copper‐Catalyzed C(sp²)–C(sp³) Cross‐Dehydrogenative Coupling of Quinones with Cyclic Alkanes: One‐Step Access to Parvaquone and its Analogs

Baral

Kim²,

Lee

2016

Asian J Org Chem

View full text Add to dashboard Cite

show abstract

Terphenylquinone Inhibitors of the Src Protein Tyrosine Kinase fromStilbellasp.

Cited by 35 publications

References 21 publications

Recent Advances on Anilato-Based Molecular Materials with Magnetic and/or Conducting Properties

Recent Advances on Anilato-Based Molecular Materials with Magnetic and/or Conducting Properties

Targeted Approaches in Natural Product Lead Discovery

Copper‐Catalyzed C(sp²)–C(sp³) Cross‐Dehydrogenative Coupling of Quinones with Cyclic Alkanes: One‐Step Access to Parvaquone and its Analogs

Contact Info

Product

Resources

About

Terphenylquinone Inhibitors of the Src Protein Tyrosine Kinase fromStilbellasp.

Cited by 35 publications

References 21 publications

Recent Advances on Anilato-Based Molecular Materials with Magnetic and/or Conducting Properties

Recent Advances on Anilato-Based Molecular Materials with Magnetic and/or Conducting Properties

Targeted Approaches in Natural Product Lead Discovery

Copper‐Catalyzed C(sp2)–C(sp3) Cross‐Dehydrogenative Coupling of Quinones with Cyclic Alkanes: One‐Step Access to Parvaquone and its Analogs

Contact Info

Product

Resources

About

Copper‐Catalyzed C(sp²)–C(sp³) Cross‐Dehydrogenative Coupling of Quinones with Cyclic Alkanes: One‐Step Access to Parvaquone and its Analogs