Terpinen-4-ol, tyrosol, and β-lapachone as potential antifungals against dimorphic fungi

Brilhante, Raimunda Sâmia Nogueira; Caetano, Érica Pacheco; Lima, Rita Amanda Chaves de; Marques, Francisca Jakelyne de Farias; Castelo-Branco, Débora de Souza Collares Maia; Melo, Charlline Vládia Silva de; Guedes, Gláucia Morgana de Melo; Oliveira, Jonathas Sales de; Camargo, Zoilo Pires de; Moreira, José Luciano Bezerra; Monteiro, André Jalles; Bandeira, Tereza de Jesus Pinheiro Gomes; Cordeiro, Rossana de Aguiar; Rocha, Marcos Fábio Gadelha; Sidrim, José Júlio Costa

doi:10.1016/j.bjm.2016.07.015

Cited by 52 publications

(27 citation statements)

References 27 publications

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“…Our results suggest that the Mesembryanthum active fraction targets the cell and nuclear membranes, as evident by the leakage of proteins and nucleic acids. These results are in agreement with those of Brilhante et al (2016) who demonstrated that tyrosol caused the leakage of protein and nucleic acids through its effect on both cellular and nuclear membrane. Their results also demonstrated the ability of tyrosol to inhibit the synthesis of ergosterol.…”

Section: Discussionsupporting

confidence: 93%

Assessment of the antifungal potential of selected desert plant extracts against pathogenic human fungi

Ibrahim

Mohamed

mohamed

et al. 2018

Egypt. J. Microbiol.

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T HE ANTIFUNGAL activities of six selected desert plants belonging to families Chenopodiaceae, Solanaceae, Brassicaceae, Fabiaceae, Zygophyllaceae and Aizoaceae from the North Western Mediterranean coastal region, Egypt, were investigated against six human pathogenic fungal species (Candida albicans, Candida tropicalis, Trichosporon sp., Aspergillus fumigatus, Aspergillus flavus and Aspergillus versicolor). Aqueous as well as organic crude extracts of the selected desert plants were screened against the different human pathogenic fungal species. Results demonstrate that the non-polar fraction of Atriplex halimus L. and Mesembryanthemum crystallinum L. exhibited the most antagonistic activity. The MIC values of fractions against yeasts and moulds ranged from 0.195 to 6.25mg/ml, whereas the fungicidal activity ranged from 0.781-12.5mg/ml. The most efficient antifungal activity was displayed by the petroleum ether fraction of M. crystallinum L. which inhibited the growth of yeast at MIC value of 0.195mg/ml and moulds at MIC values that ranged from 1.56-3.12mg/ ml. Notably, the majority of combinations between plant extracts and antifungal drugs and/or plant extracts showed synergistic antifungal activities against the tested fungal species. As for the probable mechanism for the observed antifungal activity of the petroleum ether fraction of M. crystallinum, a considerable reduction in the ergosterol content and leakage of plasma and cellular membranes of the tested fungal species.

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Section: Discussionsupporting

confidence: 93%

Assessment of the antifungal potential of selected desert plant extracts against pathogenic human fungi

Ibrahim

Mohamed

mohamed

et al. 2018

Egypt. J. Microbiol.

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“…The results showed that plant extract at a concentration of MIC/2 caused the leakage of nucleic acid (0.05) and protein (0.07) with a significant increase in absorbance higher than those obtained by control (0.01) at (260 and 280nm, respectively). These results were similar to those of Brilhante et al (2016) who reported that tyrosol caused leakage of protein and nucleic acid, emphasizing the effect of tyrosol on both cellular and nuclear membrane.…”

Section: Effect On Plasma Membrane Integritysupporting

confidence: 91%

Assessment of Environmental Fluctuations in Phytochemical Constituents of Some Xerophytes Inhabiting Wadi Sudr and Their Antimicrobial Bioactivity

2018

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T RADITIONAL medicinal plants are an important economic source of raw materials for the drug industry. Nowadays, searching for new sources of drug raw materials is an important issue to meet the ever increasing demands. Therefore, quantitative and qualitative phytochemical screening of the dominated xerophytes inhabiting Wadi Sudr, South Sinai, including Retama raetam, Reaumaria hirtella, Tamarix nilotica and Zygophyllum dumosum, was performed. The accumulation levels of some natural bioactive products including phenols, flavonoids and saponins were determined during spring and summer. The investigated species exhibited significant increases in total free amino acids during spring, while they tend to accumulate total soluble sugars, sucrose and secondary metabolites including phenols, tannins and saponins during the dry summer season. Such increments in these metabolites were concomitant with the greatly reducing power capacity. Moreover, the antimicrobial activities of extracts from these shrubs were evaluated against four pathogenic microorganisms (2 bacterial species; Escherichia coli and Staphylococcus aureus and 2 fungal species; Candida albicans and Aspergillus fumigatus). Of the tested alternatives, methanolic extract was the most active fraction, while Tamarix nilotica was the most active plant species against the four tested microorganisms, especially Candida albicans. Furthermore, The MIC of the methanolic fraction of Tamarix nilotica and its effect on ergosterol and leakage of intracellular components of cells of Candida albicans showed that this shrub displays its fungicidal effects by targeting the ergosterol biosynthesis in Candida albicans and disrupting the membrane integrity. In conclusion, these shrubs are promising new sources for potent antioxidants and useful antimicrobial agents.

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“…), terpinen‐4‐ol, tyrosol, and β ‐lapachone (Brilhante et al . ) and novel alkylated azoles (Shrestha et al . ).…”

Section: Strategies To Combat Fungal Resistancementioning

confidence: 99%

Antifungals discovery: an insight into new strategies to combat antifungal resistance

Fuentefría

Pippi

Lana

et al. 2018

Letters in Applied Microbiology

149

109

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Significance and Impact of the Study: The failure to respond to antifungal therapy is complex and is associated with microbiological resistance and increased expression of virulence in fungal pathogens. Thus, this review offers an overview of current challenges in the treatment of fungal infections associated with increased antifungal drug resistance and the formation of biofilms in these opportunistic pathogens. Furthermore, the most recent and potential strategies to combat fungal pathogens are explored here, focusing on new agents as well as innovative approaches, such as combination therapy between antifungal drugs or with natural compounds. AbstractUndeniably, new antifungal treatments are necessary against pathogenic fungi. Fungal infections have significantly increased in recent decades, being highlighted as important causes of morbidity and mortality, particularly in immunocompromised patients. Five main antifungal classes are used: (i) azoles, (ii) echinocandins, (iii) polyenes, (iv) allylamines and (v) pyrimidine analogues. Moreover, the treatment of mycoses has several limitations, such as undesirable side effects, narrow activity spectrum, a small number of targets and fungal resistance, which are still of major concern in clinical practice. The discovery of new antifungals is mostly achieved by the screening of natural or synthetic/semisynthetic chemical compounds. The most recent discoveries in drug resistance mechanism and their avoidance were explored in a review, focusing on different antifungal targets, as well as new agents or strategies, such as combination therapy, that could improve antifungal therapy.

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Terpinen-4-ol, tyrosol, and β-lapachone as potential antifungals against dimorphic fungi

Cited by 52 publications

References 27 publications

Assessment of the antifungal potential of selected desert plant extracts against pathogenic human fungi

Assessment of the antifungal potential of selected desert plant extracts against pathogenic human fungi

Assessment of Environmental Fluctuations in Phytochemical Constituents of Some Xerophytes Inhabiting Wadi Sudr and Their Antimicrobial Bioactivity

Antifungals discovery: an insight into new strategies to combat antifungal resistance

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