Terpolymer-Hydroxyapatite Hybrid Hydrogel Prepared by Photopolymerization Under Green LED Irradiation for Wound Hemostasis

Abstract

Multifunctional materials with hemostasis, adhesive, and antibacterial properties must be developed to meet the demand for wound hemostasis. In this work, a hybrid hydrogel (ATD-HAp hydrogel) based on a terpolymer and hydroxyapatite (HAp) was prepared by photopolymerization within 1 min under green LED irradiation. The polymer chains of ATD-HAp hydrogel with adjustable tensile and adhesion properties and antibacterial properties were formed by copolymerization of acrylamide, N-[tris(hydroxymethyl)methyl] acrylamide, and dimethyldiallylammonium chloride and methacrylated carboxymethyl chitosan as a cross-linking agent. HAp was added to the hydrogel to release Ca 2+ to promote coagulation. The results showed that ATD-HAp hydrogel had good tensile (196.7 kPa), wet-adhesive (10.3 kPa), self-healing, antibacterial properties, and coagulation. And the ATD-HAp hydrogel had excellent blood compatibility and biocompatibility. Furthermore, the experimental results of the hemostasis model in mice proved that the ATD-HAp hydrogel can significantly shorten the hemostasis time and reduce blood loss. Therefore, the ATD-HAp hydrogel has great potential in the field of wound hemostasis.

An Organic–Inorganic Hybrid Hydrogel Based on Chitosan for Effective Hemostasis

“…Hydroxyapatite has a similar effect to calcium carbonate and can provide adequate mechanical support for the polymer network. Hydroxyapatite is mainly distributed in the bones and teeth in humans, with good biocompatibility and is capable of releasing Ca 2+ , which can not only be used as a bone tissue engineering biological material but also promotes coagulation. , Here, hydroxyapatite was introduced into our hydrogel system to improve the mechanical properties of the hydrogel while enhancing the hemostatic effect.…”