Terramycin, a New Antibiotic

Finlay, A. C.; Hobby, Gladys L.; Pan, Si; Regna, Peter P.; Routien, John B.; Seeley, D. B.; Shull, G. M.; Sobin, B. A.; Solomons, I. A.; Vinson, Jake; Kane, J. H.

doi:10.1126/science.111.2874.85

Cited by 254 publications

(67 citation statements)

References 7 publications

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“…The results in general are similar to those described by Fildes and Whitaker (1948), Finlay et al (1950), Bryson and Demerec (1950), Hobby and Lenert (1950), Cavalli (1952), Welsch (1952), and others (of. Third Symposium of…”

supporting

confidence: 79%

Adaptation of Bacillus Megatherium to Terramycin (Oxytetracycline)

Northrop

1957

The Journal of General Physiology

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B. megatherium cultures contain a few cells per hundred million which are able to grow in the presence of terramycin. Growth of the other cells is inhibited by the antibiotic with the result that the resistant cells overgrow the culture. The resistant cells are present in the culture, without contact with terramycin, and are able to grow in the presence of terramycin, without further modification. The resistant cells are mutants of sensitive cells.

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supporting

confidence: 79%

Adaptation of Bacillus Megatherium to Terramycin (Oxytetracycline)

Northrop

1957

The Journal of General Physiology

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“…1). The dimethyamino substituent is easy to be protonated in acid media [15] and the phenolic substituent may be oxidized [16]. Figure 2 shows the anodic response of TC at the acetylene black electrode in Mcllvaine buffer solution (pH 2.5) after accumulation at open circuit for 150 s. No apparent redox response is observed in the blank buffer solution (curve a), while TC exhibits a small anodic peak at 0.68 V (curve c).…”

Section: The Voltammetric Behaviors Of Tcmentioning

confidence: 93%

Sensitivity Improvement of the Oxidation of Tetracycline at Acetylene Black Electrode in the Presence of Sodium Dodecyl Sulfate

Dang¹,

Hu²,

Wei³

et al. 2004

Electroanalysis

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The oxidation of tetracycline (TC) was investigated at an acetylene black electrode in the presence of sodium dodecyl sulfate (SDS). TC exhibited a sensitive oxidation peak in the medium system, which was attributed to the enhanced adsorption of protonated TC at the negatively charged SDS film on the electrode surface. The mechanism of the electrode process was discussed, and some experimental conditions were optimized. The oxidation peak current was proportional to TC concentration in the range of 1.2 Â 10 À7 -6.0 Â 10 À5 M, and based on three times the background signal, a detection limit of 1.2 Â 10 À8 M was obtained for 150 s accumulations. The method has been used to determine TC in honey and pharmaceutical, and the results compared favorably.

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“…Initially termed Aureomycin for its yellow hue, CTC was immediately recognized for its remarkable antibiotic properties and patented by American Cyanamid (7,8). In 1950, A. C. Finlay with Pfizer published the discovery of a similar antibiotic produced by Streptomyces rimosus that they named Terramycin (later renamed OTC) (9). Both compounds are broad-spectrum antibiotics and inhibit protein synthesis in bacteria by binding to the 30 S ribosomal subunit (10,11).…”

Section: Oxytetracycline (Otc)mentioning

confidence: 99%

Oxytetracycline Biosynthesis

Pickens¹,

Tang

2010

Journal of Biological Chemistry

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Oxytetracycline (OTC) is a broad-spectrum antibiotic that acts by inhibiting protein synthesis in bacteria. It is an important member of the bacterial aromatic polyketide family, which is a structurally diverse class of natural products. OTC is synthesized by a type II polyketide synthase that generates the poly-␤-ketone backbone through successive decarboxylative condensation of malonyl-CoA extender units, followed by modifications by cyclases, oxygenases, transferases, and additional tailoring enzymes. Genetic and biochemical studies have illuminated most of the steps involved in the biosynthesis of OTC, which is detailed here as a representative case study in type II polyketide biosynthesis.

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Terramycin, a New Antibiotic

Cited by 254 publications

References 7 publications

Adaptation of Bacillus Megatherium to Terramycin (Oxytetracycline)

Adaptation of Bacillus Megatherium to Terramycin (Oxytetracycline)

Sensitivity Improvement of the Oxidation of Tetracycline at Acetylene Black Electrode in the Presence of Sodium Dodecyl Sulfate

Oxytetracycline Biosynthesis

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