2001
DOI: 10.1016/s0921-8777(00)00057-4
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tert-Butoxyl radicals generate mainly 7,8-dihydro-8-oxoguanine in DNA

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Cited by 20 publications
(17 citation statements)
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“…Nitrosative and oxidative stress conditions were modelled by exposure to acidified sodium nitrite and t -butyl hydroperoxide, respectively (Figure 1c and d), which have been shown previously to cause these types of damage (40,41). The survival of the uvrA mutant was reduced compared with the wild-type by exposure to either of these agents.…”
Section: Resultsmentioning
confidence: 99%
“…Nitrosative and oxidative stress conditions were modelled by exposure to acidified sodium nitrite and t -butyl hydroperoxide, respectively (Figure 1c and d), which have been shown previously to cause these types of damage (40,41). The survival of the uvrA mutant was reduced compared with the wild-type by exposure to either of these agents.…”
Section: Resultsmentioning
confidence: 99%
“…[1,2] Indeed, hastening oxidative processes can lead to an altered intracellular redox status causing cellular dysfunction or death [1,2] and related events, most prominently oxidative DNA damage, [3][4][5][6] a primary process of carcinogenesis. It comes as no surprise that the development of pathogenic oxidative processes in human organism is lifestyle dependent.…”
Section: Introductionmentioning
confidence: 99%
“…They have been reported to induce strand breaks in supercoiled pBR322 DNA and may play a significant role in the tumor‐promoting activity of peroxides . Strand break formation and base oxidation have been observed as necessary modifications induced by the alkoxyl radicals in DNA damage . Tert‐B utyl hydroperoxide ( t ‐BHP) is a recognized oxidant that has been used as a model oxygen‐centered radical for the study of mechanisms of oxidative cell injury in mammalian cells and to investigate mechanisms of its interaction with polyphenols .…”
Section: Introductionmentioning
confidence: 99%