Tertiary butyl hydroperoxide induced oxidative damage in mice erythrocytes: Protection by taurine

Roy, Ajitesh; Sil, Parames C.

doi:10.1016/j.pathophys.2012.05.001

Cited by 51 publications

(36 citation statements)

References 43 publications

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“…However, these bromate‐induced alterations were attenuated by administration of taurine which could have inhibited the KBrO 3 ‐induced generation of free radicals and ROS. A similar protective effect of taurine against oxidative damage induced in blood, especially erythrocytes, by various toxicants has been previously reported by other workers (Sinha et al, ; Roy and Sil, ).…”

Section: Discussionsupporting

confidence: 87%

“…Taurine is also an AO and is a potent scavenger of the hydroxyl radical suggesting that it may be useful in treating oxygen radical pathophysiology (Ripps and Shen, ). The AO activity exhibited by taurine has been shown to protect various body organs from OS because of heavy metals, drugs, and chemicals (Sinha et al, ; Das et al, ; Manna et al, ; Alam et al, ; Roy and Sil, ; Ozden et al, ).…”

Section: Introductionmentioning

confidence: 99%

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Protective effect of taurine against potassium bromate-induced hemoglobin oxidation, oxidative stress, and impairment of antioxidant defense system in blood

Ahmad

Mahmood

2014

Environ. Toxicol.

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Potassium bromate (KBrO3 ) is widely used as a food-additive and is a major water disinfection by-product. KBrO3 causes severe toxicity in humans and experimental animals. Bromate is considered a probable human carcinogen and a complete carcinogen in animals. We have investigated the potential role of taurine in protecting against KBrO3 -induced oxidative stress in rat blood. Animals were given taurine for 5 days prior to KBrO3 and then sacrificed. Blood was collected and used to prepare hemolysates and plasma, which were then used for the analysis of several biochemical parameters. Administration of single oral dose of KBrO3 alone induced hepato- and nephro-toxicity as evident by elevated marker levels in plasma. Lipid peroxidation and protein oxidation were increased both in plasma and erythrocytes, suggesting the induction of oxidative stress. KBrO3 increased methemoglobin, nitric oxide, and hydrogen peroxide levels. It also altered the activities of the major antioxidant enzymes and lowered the antioxidant power of blood. Administration of taurine, prior to treatment with KBrO3 , resulted in significant attenuation in all these parameters but the administration of taurine alone had no effect. These results show that taurine is effective in mitigating the oxidative insult induced in rat blood by KBrO3 .

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Section: Discussionsupporting

confidence: 87%

Section: Introductionmentioning

confidence: 99%

Protective effect of taurine against potassium bromate-induced hemoglobin oxidation, oxidative stress, and impairment of antioxidant defense system in blood

Ahmad

Mahmood

2014

Environ. Toxicol.

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“…Taurine is not involved in peptide bond formation, but it has various biological functions, such as bile acid conjugation, maintenance of calcium homeostasis, osmoregulation, and membrane stabilization . In addition, antioxidant activity is another widely recognized function of taurine . Though taurine is a very stable molecule and difficult to oxidize, the sulfur‐containing acid still has an indirect antioxidant function, either by decreasing the reactive oxygen species (ROS) generation or by improving the antioxidant defense system …”

Section: Introductionmentioning

confidence: 99%

Dietary taurine supplementation improves breast meat quality in chronic heat‐stressed broilers via activating the Nrf2 pathway and protecting mitochondria from oxidative attack

et al. 2018

J Sci Food Agric

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“…Taurine (2‐aminoethanesulfonic acid) is a sulfur‐amino acid that derives from cysteine that was first discovered in 1827 by German scientists Friedrich Tiedemann and Leopold Gmelin in ox bile ( Taurus in Latin) . A main constituent of human bile salts as well, it was later identified in 1846 by Ronalds; while the mechanisms are still incompletely understood, it has since been appreciated for its role as an antioxidant, osmoprotectant, modulator of mitochondrial calcium homeostasis, and neuroprotective agent . Taurine is a nonessential amino acid, the circulating levels of which are significantly impacted by dietary intake (the normal diet typically contains 40 to 400 mg per day).…”

mentioning

confidence: 99%

Impact of taurine on red blood cell metabolism and implications for blood storage

et al. 2020

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BACKGROUND Taurine is an antioxidant that is abundant in some common energy drinks. Here we hypothesized that the antioxidant activity of taurine in red blood cells (RBCs) could be leveraged to counteract storage‐induced oxidant stress. STUDY DESIGN AND METHODS Metabolomics analyses were performed on plasma and RBCs from healthy volunteers (n = 4) at baseline and after consumption of a whole can of a common, taurine‐rich (1000 mg/serving) energy drink. Reductionistic studies were also performed by incubating human RBCs with taurine ex vivo (unlabeled or 13C15N‐labeled) at increasing doses (0, 100, 500, and 1000 μmol/L) at 37°C for up to 16 hours, with and without oxidant stress challenge with hydrogen peroxide (0.1% or 0.5%). Finally, we stored human and murine RBCs under blood bank conditions in additives supplemented with 500 μmol/L taurine, before metabolomics and posttransfusion recovery studies. RESULTS Consumption of energy drinks increased plasma and RBC levels of taurine, which was paralleled by increases in glycolysis and glutathione (GSH) metabolism in the RBC. These observations were recapitulated ex vivo after incubation with taurine and hydrogen peroxide. Taurine levels in the RBCs from the REDS‐III RBC‐Omics donor biobank were directly proportional to the total levels of GSH and glutathionylated metabolites and inversely correlated to oxidative hemolysis measurements. Storage of human RBCs in the presence of taurine improved energy and redox markers of storage quality and increased posttransfusion recoveries in FVB mice. CONCLUSION Taurine modulates RBC antioxidant metabolism in vivo and ex vivo, an observation of potential relevance to transfusion medicine.

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Tertiary butyl hydroperoxide induced oxidative damage in mice erythrocytes: Protection by taurine

Cited by 51 publications

References 43 publications

Protective effect of taurine against potassium bromate-induced hemoglobin oxidation, oxidative stress, and impairment of antioxidant defense system in blood

Protective effect of taurine against potassium bromate-induced hemoglobin oxidation, oxidative stress, and impairment of antioxidant defense system in blood

Dietary taurine supplementation improves breast meat quality in chronic heat‐stressed broilers via activating the Nrf2 pathway and protecting mitochondria from oxidative attack

Impact of taurine on red blood cell metabolism and implications for blood storage

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