Tessier Number 30 Median Mandibular Cleft With Congenital Heart Anomalies in Qena, Egypt

Ali, Ahmed

doi:10.1177/1055665618775730

Cited by 7 publications

(4 citation statements)

References 37 publications

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“…We found that the lack of miRNAs in mice led to a cleft lip‐like phenotype in the mandible. A similar symptom in humans, midline cleft of the lower lip, is known to be a rare congenital disease, which has been identified as Tessier 30 (Ali, 2019; Ladani et al, 2013; Oostrom et al, 1996). It is possible that changes in the expression of miRNAs cause the midline cleft of the lower lip in the human patient.…”

Section: Resultsmentioning

confidence: 99%

MicroRNAs regulate distal region of mandibular development through Hh signaling

et al. 2020

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Mandibular anomalies are often seen in various congenital diseases, indicating that mandibular development is under strict molecular control. Therefore, it is crucial to understand the molecular mechanisms involved in mandibular development. MicroRNAs (miRNAs) are noncoding small single‐stranded RNAs that play a critical role in regulating the level of gene expression. We found that the mesenchymal conditional deletion of miRNAs arising from a lack of Dicer (an essential molecule for miRNA processing, Dicerfl/fl;Wnt1Cre), led to an abnormal groove formation at the distal end of developing mandibles. At E10.5, when the region forms, inhibitors of Hh signaling, Ptch1 and Hhip1 showed increased expression at the region in Dicer mutant mandibles, while Gli1 (a major mediator of Hh signaling) was significantly downregulated in mutant mandibles. These suggest that Hh signaling was downregulated at the distal end of Dicer mutant mandibles by increased inhibitors. To understand whether the abnormal groove formation inDicer mutant mandibles was caused by the downregulation of Hh signaling, mice with a mesenchymal deletion of Hh signaling activity arising from a lack of Smo (an essential molecule for Hh signaling activation, Smofl/fl;Wnt1Cre) were examined. Smofl/fl;Wnt1Cre mice showed a similar phenotype in the distal region of their mandibles to those in Dicerfl/fl;Wnt1Cre mice. We also found that approximately 400 miRNAs were expressed in wild‐type mandibular mesenchymes at E10.5, and six microRNAs were identified as miRNAs with binding potential against both Ptch1 and Hhip1. Their expressions at the distal end of the mandible were confirmed by in situ hybridization. This indicates that microRNAs regulate the distal part of mandibular formation at an early stage of development by involving Hh signaling activity through controlling its inhibitor expression level.

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Section: Resultsmentioning

confidence: 99%

MicroRNAs regulate distal region of mandibular development through Hh signaling

et al. 2020

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“…Dans les formes sévères, l'épiglotte ou l´os hyoïde peuvent être absente et le cartilage thyroïdien peut être sous-développé [ 3 ]. Parfois, il peut y avoir un cordon cervical médian [ 11 ] comme dans notre cas. Les muscles hyoïdiens peuvent être atrophiques et représentés par un tissu fibreux provoquant un bombement du cou au cours de l'effort [ 10 ].…”

Section: Discussionunclassified

“…En 2001 Seyhan et al . [ 12 ] ont rapporté un cas de fente sternale associé à une cardiopathie, aussi en 2018 Ahmed Ali [ 11 ] a rapporté un cas de fente mandibulaire associé à une malformation cardiaque. À la lumière de ces données un bilan complet à la recherche d'autres malformations congénitales associées chez notre patiente a été réalisé, revenu complètement normal.…”

Section: Discussionunclassified

Fente mandibulaire médiane chez l’adulte à propos d’un cas et revue de la littérature

2021

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Les fentes oro-faciales sont des malformations congénitales fréquentes. La classification la plus utilisée est celle de Tessier qui comprend 30 variantes. Dont les fentes mandibulaires médianes (fente n°30 de Tessier) isolées ou accompagnées d´une fente de la lèvre inférieure, de la langue ou rarement du sternum. Elles sont très rares, moins de 70 cas (toutes formes confondues) ont été décrits dans la littérature. Nous rapportons un cas exceptionnel d´une fente mandibulo-sternale et nous faisons une revue de la littérature.

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“…It may be possible to support the soft tissue repair with resorbable fixation or a resorbable suture. A number of cases would seem to have made use of this in the repair of this cleft (Ladani et al, 2013; Rao et al, 2015; Scheckter et al, 2018; Walker et al, 2019a; Ali, 2019).…”

Section: Discussionmentioning

confidence: 99%

Tessier 30 Facial Clefts—A Literature Review of 72 Cases (1996-2020), Suggested Treatment Protocol, Outcome Measures, Minimum Dataset for Future Case Reports, and Registries

Valk

Magill

Pellatt

et al. 2021

The Cleft Palate Craniofacial Journal

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Introduction: Tessier 30 facial cleft is a rare anomaly presenting in the soft and hard tissues over the central lower face. Owing to the rarity of cases and difficulty of treatment, there is no universally accepted surgical management strategy. The last comprehensive literature review of Tessier 30 clefts was in 1996. This report aims to update the literature to inform decision-making on treating Tessier 30 cases. Methodology: A literature search was performed. PubMed, SCOPUS, and OVID databases were searched. A total of 72 cases in 51 articles were analyzed, looking at demographics, extent of cleft, parent health, family history, procedures, follow-up, existence of other anomalies, and stages of repair. Results: Surgeons are increasingly choosing to repair Tessier 30 defects in one rather than multiple stages. Of the 72 cases studied, only 31 had documented the completed repair of the cleft. All completed soft tissue only defects were repaired in 1 stage of repair (n = 11). Where both soft tissue and mandible was involved (n = 20), 55% (n = 11) had undergone 1-stage repair to address the Tessier 30 cleft. Discussion: We argue that a single-stage approach is preferable to multistage. Primary mucogingivoperiosteoplasty should be undertaken in children at the time of management of the soft tissue cleft. The timing of this procedure should be in the latter half of the first year of life, as this is when mandibular symphyseal fusion normally occurs. We have suggested a treatment protocol and we hope that future case reports use our minimum data set.

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Tessier Number 30 Median Mandibular Cleft With Congenital Heart Anomalies in Qena, Egypt

Cited by 7 publications

References 37 publications

MicroRNAs regulate distal region of mandibular development through Hh signaling

MicroRNAs regulate distal region of mandibular development through Hh signaling

Fente mandibulaire médiane chez l’adulte à propos d’un cas et revue de la littérature

Tessier 30 Facial Clefts—A Literature Review of 72 Cases (1996-2020), Suggested Treatment Protocol, Outcome Measures, Minimum Dataset for Future Case Reports, and Registries

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