Test-retest reliability and validity of a frustration paradigm and irritability measures

Tseng, Wan Ling; Moroney, Elizabeth; Machlin, Laura; Roberson‐Nay, Roxann; Hettema, John M.; Carney, Dever M.; Stoddard, Joel; Towbin, Kenneth; Pine, Daniel S.; Leibenluft, Ellen; Brotman, Melissa A.

doi:10.1016/j.jad.2017.01.024

Cited by 48 publications

(22 citation statements)

References 29 publications

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“…Participants completed a frustrating attention task, the Affective Posner 2 paradigm (29). This was adapted from a prior fMRI study (19) and demonstrates good reliability and validity (29). Participants were asked to identify a target following a cue by button press (left or right).…”

Section: Methodsmentioning

confidence: 99%

Brain Mechanisms of Attention Orienting Following Frustration: Associations With Irritability and Age in Youths

Tseng¹,

Deveney

Stoddard

et al. 2019

AJP

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Objective: Childhood irritability is a common, impairing problem with changing agerelated manifestations that predict long-term adverse outcomes. However, more work is needed on its overall and age-specific neural correlates. Since irritable youth exhibit exaggerated responses to frustrating stimuli, we used a frustrating functional magnetic resonance imaging (fMRI) paradigm to examine associations between irritability and neural activation and tested the moderating effect of age. Method: We studied a transdiagnostic sample of 195 youths with varying levels of irritability (52 disruptive mood dysregulation disorder, 42 anxiety disorder, 40 attention deficit/hyperactivity disorder, and 61 healthy volunteers). Irritability was measured by parent- and child-reports on the Affective Reactivity Index. The fMRI paradigm was a cued-attention task differentiating neural activity in response to frustration (rigged feedback) from activity during attention orienting in the trial following frustration. Results: Whole-brain activation analyses revealed associations with irritability during attention orienting following frustration. Irritability was positively associated with frontalstriatal activation, specifically in dorsolateral prefrontal cortex, inferior frontal gyrus, and caudate (rs=.31-.40, ps<.05). Age moderated the association between irritability and activation in some frontal and posterior regions (anterior cingulate cortex [ACC], medial frontal gyrus, cuneus, precuneus, superior parietal lobule; F1,189=19.04–28.51, ps<.001, ηp2=.09-.13). Specifically, higher irritability was more strongly related to increased activation in younger relative to older youths. Conclusions: Following frustration, levels of irritability correlate with activity in neural systems mediating attention orienting, top-down regulation of emotions, and motor execution. While most associations were independent of age, dysfunction in ACC and posterior regions was more pronounced in young children with irritability.

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Section: Methodsmentioning

confidence: 99%

Brain Mechanisms of Attention Orienting Following Frustration: Associations With Irritability and Age in Youths

Tseng¹,

Deveney

Stoddard

et al. 2019

AJP

Self Cite

101

123

View full text Add to dashboard Cite

show abstract

“…Prior work supports the ARI’s unidimensionality and demonstrates its excellent internal consistency and good test–retest reliability and convergent and predictive validity in clinical and community samples (Mulraney et al, 2014; Stringaris, Goodman, et al, 2012). The ARI has been used with school-aged children (aged 9 years and older) and adolescents (Melvin et al, 2018; Mulraney et al, 2014; Tseng et al, 2017). In addition to the ARI, Wakschlag and colleagues (Wakschlag et al, 2012; Wakschlag et al, 2015) used developmentally sensitive quantitative methods, including item response theory (IRT), to develop the parent-report Multidimensional Assessment Profile of Disruptive Behavior (MAP-DB) Temper Loss scale (22 items) for preschool-age children; data support the scale as a reliable and valid measure that captures the full spectrum of irritability in early childhood (Wakschlag et al, 2012; Wakschlag et al, 2015; Wiggins et al, 2018).…”

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confidence: 99%

Using Item Response Theory to Compare Irritability Measures in Early Adolescent and Childhood Samples

et al. 2020

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Limited psychometric information is available to guide best practices for measuring youth irritability. This report compares performance of irritability measures using item response theory (IRT). Study 1 used a sample of 482 early adolescents and compared the parent- and youth-report affective reactivity index (ARI) and irritability factors derived from the parent-report Child Behavior Checklist (CBCL) and clinician-administered Kiddie Schedule for Affective Disorders (K-SADS). Study 2 combined data from three childhood samples ( N = 811) and compared performance of the parent-report ARI and CBCL and the clinician-administered Preschool Age Psychiatric Assessment (PAPA). The ARI emerged as the best measure of childhood irritability across the developmental periods, while the CBCL and K-SADS provided an adequate amount of information in early adolescents. No measure reliably assessed irritability at modest severity levels. Using IRT across large pools of developmental samples and measures is needed to guide the field in the measurement of youth irritability.

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“…We also measured the level of irritability, which is highly prevalent among patients with DBD. Irritability was operationalized as summation of three items on the CBCL questionnaire (“temper tantrum or hot temper”, “stubborn, sullen, or irritable”, and “sudden changes in mood or feelings”), which have been shown to produce valid and reliable measurement of irritability in pediatric populations [ 43 ]. Post-intervention scores were collected at the date of completion of their continuous participation with the program, regardless of the reason for completing the program.…”

Section: Methodsmentioning

confidence: 99%

Effectiveness of Stimulant Medications on Disruptive Behavior and Mood Problems in Young Children

Parsley

Zhang

Hausmann³

et al. 2020

Clin Psychopharmacol Neurosci

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Objective There are very few studies on the effectiveness of stimulant medications for the treatment of disruptive mood and behavior problems in young children (less than 7 years) with Disruptive Behavior Disorders (DBD). The current study aims to determine whether young children (ages 4−7) in a long-term, intensive outpatient behavioral treatment program who are receiving stimulant medications show greater improvement in mood and behavior problems compared to peers who did not. Methods A retrospective chart review was conducted for 97 participants diagnosed with DBD, aged 4−7 years old who were enrolled in an intensive outpatient behavioral intervention program. Pre- and post-intervention Child Behavior Checklist (CBCL) scores for disruptive behavior and mood problems were compared between the children who received stimulant medications and those who did not. Results Paired t tests showed a statistically significant improvement in CBCL outcomes between pre- and post-intervention scores of disruptive behavior and mood problems. ANCOVA analysis, however, showed no clear further improvement in those same CBCL scores in the participants who received stimulant medications compared to the participants who did not. CBCL scores for Conduct Disorder were marginally significant for less improvement for the participants who received stimulant medications. Conclusion This retrospective review suggests a possibility that stimulant medications may not provide additional benefit for the long-term treatment of disruptive behavior and mood problems in young children under age 7. Future study is warranted to evaluate the efficacy/effectiveness of stimulant medications in the treatment of disruptive behavior and mood problems in this population.

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Test-retest reliability and validity of a frustration paradigm and irritability measures

Abstract: The Affective Posner 2 paradigm and the ARI and CBCL irritability scales may be useful tools for longitudinal or treatment research on irritability.

Cited by 48 publications

References 29 publications

Brain Mechanisms of Attention Orienting Following Frustration: Associations With Irritability and Age in Youths

Brain Mechanisms of Attention Orienting Following Frustration: Associations With Irritability and Age in Youths

Using Item Response Theory to Compare Irritability Measures in Early Adolescent and Childhood Samples

Effectiveness of Stimulant Medications on Disruptive Behavior and Mood Problems in Young Children

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