Test-retest reliability of tibiofemoral joint space width measurements using low-dose standing CT

Segal, N.A.; Bergin, J.; Findlay, C.; Anderson, David

doi:10.1016/j.joca.2015.02.435

Cited by 1 publication

(1 citation statement)

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“…≤0.1 mm for the trabeculae). Recently introduced extremity cone-beam CT (CBCT) systems [1]–[3] based on amorphous silicon (a-Si:H) Flat Panel Detectors (FPD) can resolve ~250 μm details in high-resolution imaging modes. This improved spatial resolution compared to conventional CT, combined with advantages of logistics, radiation dose and capability for weight-bearing imaging, position extremity CBCT as an attractive platform for comprehensive evaluation of all aspects of bone and joint health.…”

Section: Introductionmentioning

confidence: 99%

High-resolution extremity cone-beam CT with a CMOS detector: evaluation of a clinical prototype in quantitative assessment of bone microarchitecture

Cao

Brehler

Sisniega

et al. 2018

Medical Imaging 2018: Physics of Medical Imaging

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Purpose: A prototype high-resolution extremity cone-beam CT (CBCT) system based on a CMOS detector was developed to support quantitative in vivo assessment of bone microarchitecture. We compare the performance of CMOS CBCT to an amorphous silicon (a-Si:H) FPD extremity CBCT in imaging of trabecular bone. Methods: The prototype CMOS-based CBCT involves a DALSA Xineos3030 detector (99 μm pixels) with 400 μm-thick CsI scintillator and a compact 0.3 FS rotating anode x-ray source. We compare the performance of CMOS CBCT to an a-Si:H FPD scanner built on a similar gantry, but using a Varian PaxScan2530 detector with 0.137 mm pixels and a 0.5 FS stationary anode x-ray source. Experimental studies include measurements of Modulation Transfer Function (MTF) for the detectors and in 3D image reconstructions. Image quality in clinical scenarios is evaluated in scans of a cadaver ankle. Metrics of trabecular microarchitecture (BV/TV, Bone Volume/Total Volume, TbSp, Trabecular Spacing, and TbTh, trabecular thickness) are obtained in a human ulna using CMOS CBCT and a-Si:H FPD CBCT and compared to gold standard μCT. Results: The CMOS detector achieves ~40% increase in the f20 value (frequency at which MTF reduces to 0.20) compared to the a-Si:H FPD. In the reconstruction domain, the FWHM of a 127 μm tungsten wire is also improved by ~40%. Reconstructions of a cadaveric ankle reveal enhanced modulation of trabecular structures with the CMOS detector and soft-tissue visibility that is similar to that of the a-Si:H FPD system. Correlations of the metrics of bone microarchitecture with gold-standard μCT are improved with CMOS CBCT: from 0.93 to 0.98 for BV/TV, from 0.49 to 0.74 for TbTh, and from 0.9 to 0.96 for TbSp. Conclusion: Adoption of a CMOS detector in extremity CBCT improved spatial resolution and enhanced performance in metrics of bone microarchitecture compared to a conventional a-Si:H FPD. The results support development of clinical applications of CMOS CBCT in quantitative imaging of bone health.

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Section: Introductionmentioning

confidence: 99%