Test–retest repeatability and software reproducibility of myocardial flow measurements using rest/adenosine stress Rubidium-82 PET/CT with and without motion correction in healthy young volunteers

Abstract

Background. Myocardial flow reserve (MFR) assessment with cardiac positron emission computed tomography (PET/CT) is well established, and quantification relies on commercial software packages. However, for reliable use, repeatability and reproducibility are important. The aim of this study was therefore to investigate and compare between scans and software packages the repeatability and reproducibility of 82 Rb-PET/CT estimated MFR.Methods and Results. Forty healthy volunteers completed two 82 Rb-PET/CT rest and adenosine stress scans. syngo.MBF (Siemens), quantitative-gated SPECT (QGS) (Cedars-Sinai), and Corridor4DM (4DM) were used for analyses. Motion correction was available for 4DM. Fifty percent were men and age was 24 ± 4 years (mean ± SD). Repeatability of MFR varied between scans. syngo.MBF: mean difference (95% CI) 0.26 (2 0.03 to 0.54),

Multiparametric Cardiac 18F-FDG PET in Humans: Kinetic Model Selection and Identifiability Analysis

“…The study did not consider motion correction, which could affect the accuracy of kinetic quantification [45][46][47][48]. Nevertheless, the effect of motion is not expected to result in a significant change to the results of this study since the spatial resolution of the PET scanner is only about 6-8 mm and the quantification was performed on large, global ROIs.…”

Doppler Echocardiography Assessment of Coronary Microvascular Function in Patients With Angina and No Obstructive Coronary Artery Disease

“…Internal reproducibility of the CFVR results were good and therefore not the cause of the modest agreement between methods, while PET examinations were not repeated. Interestingly, other studies of MBFR measurement found only modest agreement between repeated PET examinations (107,108). Overall, it was concluded that CFVR and MBFR in ANOCA patients are not interchangeable, possibly due to the methodological differences.…”

Myocardial perfusion reserve in patients with chronic hepatitis C before and after direct‐acting antiviral treatment—a pilot study

“…All PET acquisitions, targeting injection doses of 1100 MBq 82 Rb supplied from a CardioGen‐82 Sr‐82/Rb‐82 generator (Bracco Diagnostics Inc.), were obtained in three‐dimensional mode on a 128‐slice Biograph mCT PET/CT system (Siemens Healthineers) and stored in list‐mode format (Murthy et al, 2018 ). Pharmacologic stressing was obtained using adenosine infused at 140 mcg/kg/min for 6 min with PET emission acquisition starting 2.5 min into the infusion, Before the rest scans, the patients underwent a low‐dose CT for attenuation–correction purposes (120 kVp; effective tube current, 26 mA [11 mAs quality reference]) acquired using a free‐breathing protocol (Byrne et al, 2021 ). Coronary artery calcium score (CACS) images were acquired from a noncontrast breath‐hold CT scan and CACS was calculated according to the Agatston score (Agatston et al, 1990 ).…”