Test-retest repeatability in macular retinal oximetry

Smith, Jennyffer D; Bisignano, Kelly; Harrison, Wendy W

doi:10.1080/08164622.2023.2261928

Cited by 2 publications

(2 citation statements)

References 28 publications

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“…The protocol for recording oxygen saturation levels is our standard method first described in Williams et al 15 Only the right eye was included. Data was gathered using an oximeter/fundus camera (Zilia Ocular, Zilia Inc, Quebec, Canada) after the instrument was calibrated for each subject.…”

Section: Methodsmentioning

confidence: 99%

“…Previous studies with this instrument arise largely from our group and find the instrument to have good repeatability, as well as high sensitivity to circadian rhythms in control populations. 15 , 16 The detailed principles of how this technology works are described in other publications. These papers also illustrate how the depth of the oximeter is known to typically include the retina up to the RPE.…”

Section: Introductionmentioning

confidence: 99%

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Variations in Retinal Oxygen Saturation in a Diverse Healthy Population

Bisignano,

Smith,

Harrison

2024

OPTO

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Purpose Local retinal oxygen saturation is a research technique, which has the potential as a biomarker for diabetes. However, normative data has not been established. This study examined differences in oxygen saturation around the macula and characterizes the relationship between age, race, refractive error (RE), sex, blood pressure (BP), prediabetic status and oxygen saturation. Methods Fifty-nine subjects aged 22–69 (38.8 ± 14.7 years) were included who were racially diverse and with equal gender distribution. None had eye disease. Oxygen saturation was taken with the Zilia Ocular in 4 locations around the macula 3.1 degrees from the fovea and they were also averaged. BP, RE, and HbA1c were noted. Regression analyses for oximetry and other factors were completed as were t -tests with multiple comparison corrections. Results There were significant variations in oximetry measures by race, with higher pigmentation levels associated with lower oximetry values (p < 0.01). There was no relationship between oximetry and sex (p = 0.34), RE (p = 0.67), BP (systolic p = 0.61, diastolic p = 0.71) nor prediabetic status (p = 0.87). Oximetry was associated with age when controlling for race (P < 0.002). Nasal-temporal variations showed nasal oximetry to higher than temporal measures (P < 0.01). Conclusion This study revealed race/pigmentation is an important influence on oximetry measures. Retinal location also caused variations, likely due to proximity to larger vessels nasally. No differences in sex, RE nor BP were observed to alter local oxygen saturation. However, age was correlated when considered with race. This study will inform our future work in different disease states and is an important first step in evaluating this technology.

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Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Variations in Retinal Oxygen Saturation in a Diverse Healthy Population

Bisignano,

Smith,

Harrison

2024

OPTO

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Relationship Between Retinal Oxygen Saturation and the Severity of Visual Field Damage in Glaucoma

Mahmoudinezhad,

Moghimi,

Micheletti

et al. 2024

Journal of Glaucoma

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Précis: Increased oxygen saturation was significantly associated with the severity of VF damage in glaucoma patients. Purpose: To investigate the association between retinal oxygen saturation (StO2) % and the severity of visual field (VF) loss in glaucoma. Methods: A total of 198 eyes from 131 glaucoma patients were included in this cross-sectional study. Participants underwent imaging using ocular oximetry (Zilia; Quebec City, Canada) and 24-2 SITA standard VF (Carl Zeiss-Meditec, San Leandro). StO2 (%), was measured at 2 locations of the peripapillary optic nerve head (ONH) (superotemporal, and inferotemporal). Measurements were reported as the mean of at least 5 measurements in each location. Associations between the severity of VF loss, reported as mean deviation (MD), and StO2 (%) was calculated. Results: 198 eyes of 131 patients (mean (95% CI) age, 71.1 (68.9,73.3) years, 68 females [51.9%], 63 males (48.1%)) were analyzed. In univariable analysis, higher StO2 −0.06 (−0.12, 0.00) was associated with severity in all hemifields (P=0.047). Multivariate regression analysis showed that each 1% increase in StO2 was associated with −0.06 (−0.12,-0.00) dB loss in MD in all hemifields (P=0.043). In multivariate regression analysis in the superior hemifields, higher StO2 −0.07 (−0.16, 0.01) tended to be associated with superior hemifield severity (P=0.09). Conclusions: Retinal oximetry enabled the continuous quantitative measurement of retinal StO2. Increased StO2 was significantly associated with the severity of VF damage in glaucoma patients.

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Test-retest repeatability in macular retinal oximetry

Cited by 2 publications

References 28 publications

Variations in Retinal Oxygen Saturation in a Diverse Healthy Population

Variations in Retinal Oxygen Saturation in a Diverse Healthy Population

Relationship Between Retinal Oxygen Saturation and the Severity of Visual Field Damage in Glaucoma

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