Testicular Androgen Production Under Long-Term HCG Treatment in Adults With Chronic Renal Failure

Bundschu, H. D.; Pfeiffer, Esther; Eichner, Martin; Hayduk, K

doi:10.1530/acta.0.080s141

Acta Endocrinologica

1975

DOI: 10.1530/acta.0.080s141

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Testicular Androgen Production Under Long-Term HCG Treatment in Adults With Chronic Renal Failure

H. D. Bundschu¹,

Esther Pfeiffer²,

Martin Eichner³

et al.

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1978

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“…Because the Leydig cells of uremic patients are found to respond to exogenous stimulation with increased T production (Nieschlag and Kley, 1974; No.2 hCG TREATMENT FOR IMPOTENCE OF UREMIA· Canale et al 121 Stewart-Bentley et al, 1974;Bundschu et al, 1975;Lim et al, 1978), and because this increase causes an improvement in sexual function (Nieschlag and Loriaux, 1972;Cooper et al, 1970;Van Kammen et al, 1975;Davidson et al, 1979), we investigated the effects of long-term hCG administration in patients either on chronic hemodialysis or undergoing conservative diet therapy alone.…”

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confidence: 99%

Human Chorionic Gonadotropin Treatment of Male Sexual Inadequacy in Patients Affected by Chronic Renal Failure

Canale

Barsantini

Minervini

et al. 1984

Journal of Andrology

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Twenty patients with sexual inadequacies secondary to different degrees of chronic renal failure were investigated. The patients were divided into two groups: group A—ten patients treated with a conservative diet therapy; group B—ten patients on hemodialysis. All the patients under investigation were administered 2000 IU of hCG every other day for 120 days after a 30‐day period without treatment. Andrologic, biometric, hematologic, and sexual data were evaluated before and after hormone treatment. Sexual parameters were collected through self‐evaluation by the patients and their partners. Our results agree with Van Kammen et al (1975) and show an improvement of the andrologic and biometric data in patients from group A. Furthermore, eight patients form group A and three patients from group B reported a remarkable improvement in their sexual responses.

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confidence: 99%

Human Chorionic Gonadotropin Treatment of Male Sexual Inadequacy in Patients Affected by Chronic Renal Failure

Canale

Barsantini

Minervini

et al. 1984

Journal of Andrology

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Sex Hormones in Male Patients With Chronic Renal Failure. I. The Production of Testosterone and of Androstenedione

Kammen

Thijssen

Schwärz

1978

Clinical Endocrinology

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SUMMARY The production of testosterone (Te) and androstenedione (A) has been studied in twenty‐three patients with chronic renal failure. Four of the patients were being prepared for haemodialysis (HD) treatment — non‐HD patients — nineteen were on chronic HD treatment, five of whom had been nephrectomized bilaterally. Data are presented on plasma Te and A levels, on the response to HCG and on changes after HD. The Metabolic Clearance Rate (MCR), blood production rate and the mutual interconversion of both steroids were determined together with the plasma sex hormone binding globulin capacity. In all groups of patients, plasma levels of Te were low and stimulation with HCG resulted in an insufficient increase in plasma Te levels, indicating Leydig cell deficiency in chronic uraemic males. In addition, a tendency to increased metabolic breakdown of Te was observed, most probably caused by a deficient synthesis of the sex hormone binding globulin. In patients with high peripheral degradation of Te, the testicles were able to produce about normal amounts of Te. In the non‐HD patients an increase in the MCR and blood production rate of A was found. This may be due to an alteration in the testicular steroid secretion. The other groups of patients did not show differences in the production of A when compared with normal males. No significant changes in plasma levels of Te and A were observed during HD treatment. The picture emerging from our data is similar to the one observed in population groups with severe protein malnutrition.

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Testicular Androgen Production Under Long-Term HCG Treatment in Adults With Chronic Renal Failure

Cited by 2 publications

References 0 publications

Human Chorionic Gonadotropin Treatment of Male Sexual Inadequacy in Patients Affected by Chronic Renal Failure

Human Chorionic Gonadotropin Treatment of Male Sexual Inadequacy in Patients Affected by Chronic Renal Failure

Sex Hormones in Male Patients With Chronic Renal Failure. I. The Production of Testosterone and of Androstenedione

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