Testicular asymmetry in healthy adolescent boys

Vaganée, Donald; Daems, Frans; Aerts, William; Dewaide, Rosina; Keybus, Tinne van den; Baets, Karen De; Wachter, Stefan De; Win, Gunter De

doi:10.1111/bju.14174

Cited by 33 publications

(19 citation statements)

References 44 publications

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“…Similarly, on evaluating the pathological anatomy of patients with COVID-19-related pneumonia, X-ray images showed rapid progression of pneumonia and some differences between the left and right lungs. 6 In a study performed by Vaganée et al, 7 approximately 78%-93% of varicoceles are shown to appear on the left side, and a smaller left testis is more frequently observed on comparing patients with varicoceles and healthy adolescents. Collectively, there are differences in pathophysiological and biological functions between the left and right sides of paired organs, but the underlying molecular basis causing these differences remains unknown.…”

Section: Introductionmentioning

confidence: 95%

MicroRNA Profiling in Paired Left and Right Eyes, Lungs, and Testes of Normal Mice

Shi¹,

Hu²,

Zhou³

et al. 2020

Molecular Therapy - Nucleic Acids

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Physiological and pathophysiological differences widely exist in paired organ systems. However, the molecular basis for these differences remains largely unknown. We previously reported that there exist differentially expressed miRNAs (DEMs) in the left and right kidneys of normal mice. Here, we identified the DEMs in the left and right eyes, lungs, and testes of normal mice via RNA sequencing. As a result, we identified 26 DEMs in eyes, with 23 higher and 3 lower in the left eyes compared with right eyes; 21 DEMs in lungs, with 15 higher and 6 lower in the left lungs compared with right lungs; and 54 DEMs in testes, with 6 higher and 48 lower in the left testes compared with right testes. Ten microRNAs (miRNAs) were further examined by quantitative PCR assays, and seven of these were confirmed. In addition, correlation analysis was performed between paired organ miRNA expressions and diverse body fluid miRNA expressions. Finally, we explored the functions and networks of DEMs and performed biological process and pathway enrichment analysis of target genes for DEMs, providing insights into the physiological and pathophysiological differences between the two entities of paired organs.

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Section: Introductionmentioning

confidence: 95%

MicroRNA Profiling in Paired Left and Right Eyes, Lungs, and Testes of Normal Mice

Shi¹,

Hu²,

Zhou³

et al. 2020

Molecular Therapy - Nucleic Acids

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“…6 There are data to support the view that testicular asymmetry in adolescent men needs to be regarded with caution and is not an indication to treat on a single measurement alone. 7 However, in their meta-analysis Silay et al suggest that improvement in pain attributed to varicocele following repair may be seen in up to 100% of patients, although data are limited. 8 It does seem to be the case that correction of a varicocele where the left testis is ≥20% (or ≥2ml) smaller than the right side will lead to an improvement in semen parameters and a catch-up testicular growth, but no data reliably support a functional benefit.…”

Section: Varicocelementioning

confidence: 99%

Five common urological problems affecting adolescent men

Tregunna¹,

Wood

2021

Trends Urol & Men's Health

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“…Die Hodenvolumendifferenz verliert darüber hinaus an Relevanz für das Varikozelenmanagement, da in einer Observationsstudie an 539 gesunden Jungen im Alter von 11 -16 Jahren ohne Begleiterkrankungen, von denen 345 ausgewertet werden konnten, bei jedem 5. Jungen eine Hodenvolumendifferenz > 2 ml oder > 20 % (mit einer Volumenreduktion des linken Hodens) beobachtet wurde [13].…”

Section: Introductionunclassified

Varikozele im Jugendalter, wenn ja, wann und wie? Kontra OP

Kliesch

2019

Aktuel Urol

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ZusammenfassungDie verfügbaren Indikatoren, die eine Therapie der Varikozele beim Adoleszenten rechtfertigen sollen, sind unzureichend: Das Hodenvolumen ist als störanfälliger Messparameter variabel, eine Hodenvolumendifferenz kann physiologisch sein; Hodenvolumen und Samenparameter unterliegen der pubertären Entwicklung. Beide Parameter sollten von daher prospektiv und zu mehreren Zeitpunkten gemessen werden, um eine klare Aussage im Hinblick auf eine mögliche Funktionseinschränkung der Hoden durch eine Varikozele treffen zu können. Nahezu unbeachtet sind endokrine Parameter der Hodenentwicklung, die möglicherweise pathologische Abweichungen anzeigen könnten. Völlig unklar ist der postulierte positive Effekt auf die spätere Fertilität der Betroffenen im Erwachsenenalter: Die wenigen vorliegenden Studien können nicht zeigen, dass eine effektive Prävention einer späteren Fertilitätseinschränkung durch eine frühzeitige Therapie der Varikozele beim Jugendlichen möglich ist. Aus diesen Gründen müssen Risiken und Nutzen der Therapie sorgfältig abgewogen werden. Eine evidenzgesicherte Empfehlung zur Intervention beim Jugendlichen lässt sich aus der aktuellen Datenlage nicht ableiten.

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Testicular asymmetry in healthy adolescent boys

Cited by 33 publications

References 44 publications

MicroRNA Profiling in Paired Left and Right Eyes, Lungs, and Testes of Normal Mice

MicroRNA Profiling in Paired Left and Right Eyes, Lungs, and Testes of Normal Mice

Five common urological problems affecting adolescent men

Varikozele im Jugendalter, wenn ja, wann und wie? Kontra OP

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