Testicular Atrophy in a Mule Deer Population

Tiller, Brett L.; Dagle, G.E.; Cadwell, L.L.

doi:10.7589/0090-3558-33.3.420

Cited by 17 publications

(15 citation statements)

References 7 publications

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“…Thus, 12 weeks after the infection of male cats with FeLV, much lower levels of testicular testosterone production were observed following the injection of human chorionic gonadotropin in infected cats than in uninfected cats (346). Other glands, such as the hypothalamus and pituitary were also affected, with lower levels of The monitoring of mule deer on a former plutonium production site revealed that 27% of the 116 adult males had abnormally developed testicles associated with low levels of testosterone in serum and compensatory high levels of LH and FSH (328). The severity of the atrophy and the absence of other affected tissues suggested that radiation might not be the cause.…”

Section: The Animal Testismentioning

confidence: 99%

Viruses in the Mammalian Male Genital Tract and Their Effects on the Reproductive System

Dejucq

Jégou

2001

Microbiol Mol Biol Rev

290

220

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This review describes the various viruses identified in the semen and reproductive tracts of mammals (including humans), their distribution in tissues and fluids, their possible cell targets, and the functional consequences of their infectivity on the reproductive and endocrine systems. The consequences of these viral infections on the reproductive tract and semen can be extremely serious in terms of organ integrity, development of pathological and cancerous processes, and transmission of diseases. Furthermore, of essential importance is the fact that viral infection of the testicular cells may result not only in changes in testicular function, a serious risk for the fertility and general health of the individual (such as a fall in testosteronemia leading to cachexia), but also in the possible transmission of virus-induced mutations to subsequent generations. In addition to providing an exhaustive account of the data available in these domains, this review focuses attention on the fact that the interface between endocrinology and virology has so far been poorly explored, particularly when major health, social and economical problems are posed. Our conclusions highlight the research strategies that need to be developed. Progress in all these domains is essential for the development of new treatment strategies to eradicate viruses and to correct the virus-induced dysfunction of the endocrine system

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Section: The Animal Testismentioning

confidence: 99%

Viruses in the Mammalian Male Genital Tract and Their Effects on the Reproductive System

Dejucq

Jégou

2001

Microbiol Mol Biol Rev

290

220

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“…Elsewhere, deer with abnormal antlers and atrophic scrotal testes have been reported (Chapman et al 1984; Tiller et al 1997). Occasionally, males of other deer species lacking scrotal testes have been reported (Hofmann 1968; Leader-Williams 1979; Marburger et al 1967), but they had normal antlers.…”

mentioning

confidence: 99%

Testis and Antler Dysgenesis in Sitka Black-Tailed Deer on Kodiak Island, Alaska: Sequela of Environmental Endocrine Disruption?

Veeramachaneni

Amann

Jacobson³

2006

Environ Health Perspect

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It had been observed that many male Sitka black-tailed deer (Odocoileus hemionus sitkensis) on Kodiak Island, Alaska, had abnormal antlers, were cryptorchid, and presented no evidence of hypospadias. We sought to better understand the problem and investigated 171 male deer for phenotypic aberrations and 12 for detailed testicular histopathology. For the low-lying Aliulik Peninsula (AP), 61 of 94 deer were bilateral cryptorchids (BCOs); 70% of these had abnormal antlers. Elsewhere on the Kodiak Archipelago, only 5 of 65 deer were BCOs. All 11 abdominal testes examined had no spermatogenesis but contained abnormalities including carcinoma in situ–like cells, possible precursors of seminoma; Sertoli cell, Leydig cell, and stromal cell tumors; carcinoma and adenoma of rete testis; and microlithiasis or calcifications. Cysts also were evident within the excurrent ducts. Two of 10 scrotal testes contained similar abnormalities, although spermatogenesis was ongoing. We cannot rule out that these abnormalities are linked sequelae of a mutation(s) in a founder animal, followed by transmission over many years and causing high prevalence only on the AP. However, based on lesions observed, we hypothesize that it is more likely that this testis–antler dysgenesis resulted from continuing exposure of pregnant females to an estrogenic environmental agent(s), thereby transforming testicular cells, affecting development of primordial antler pedicles, and blocking transabdominal descent of fetal testes. A browse (e.g., kelp) favored by deer in this locale might carry the putative estrogenic agent(s).

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“…Extensive investigation found no relationships between the presence of testicular atrophy and contaminant levels, diet, disease, or natural conditions such as aging or genetics (Tiller et al 1997). Testicular atrophy in male mule deer is associated with abnormal antler growth manifest as misshapen, velvet-covered antlers, which 5% of the northern region and 5% of the southern region male deer affected.…”

Section: Mule Deer K D Hand and J A Stegenmentioning

confidence: 99%

“…In the early 1990s, testicular atrophy and sterility were observed in some male mule deer on the Hanford Site (Tiller et al 1997;PNNL-11518). Extensive investigation found no relationships between the presence of testicular atrophy and contaminant levels, diet, disease, or natural conditions such as aging or genetics (Tiller et al 1997).…”

Section: Mule Deer K D Hand and J A Stegenmentioning

confidence: 99%

Hanford Site Environmental Report for Calender Year 2006

Poston¹,

Hanf²,

Dirkes³

2007

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The cover photo shows rabbitbrush on the Hanford Site with the White Bluffs along the Columbia River in the background. The photo is from Lockheed Martin Information Technology, Richland, Washington. The cover design is by SB Neely, Pacific Northwest National Laboratory, Richland, Washington.This document was printed on recycled paper. HANFORD SITEE PrefaceThe Hanford Site environmental report is prepared annually for the U.S. Department of Energy (DOE) in accordance with the requirements in DOE Manual 231.1-1A, "Environment, Safety, and Health Reporting Manual," and DOE Order 231.1A, "Environment, Safety, and Health Reporting." The report provides an overview of activities at the site; demonstrates the status of the site's compliance with applicable federal, state, and local environmental laws and regulations, executive orders, and DOE policies and directives; and summarizes environmental data that characterize Hanford Site environmental management performance. The report also highlights significant environmental and public protection programs and efforts. Some historical and early 2007 information is included where appropriate. More detailed environmental compliance, monitoring, and surveillance information is provided in additional reports referenced in the text.Although this report was primarily written to meet DOE reporting requirements and guidelines, it is also intended to provide a broad spectrum of environmental and environmentally related information to DOE managers, the public, Indian tribes, public officials, regulatory agencies, Hanford Site contractors, and elected representatives. Appendix A lists scientific notation, units of measure, unit conversion information, and nomenclature that may help readers understand the report. Appendix B is a glossary of terms. Report AvailabilityThis report was produced in both paper and electronic formats. The paper formats include this technical report, two supplemental data appendixes, and a less-detailed summary report (PNNL-16623-SUM). Electronically, the report is available in portable document format (PDF) on compact disk and at the following website: http://hanfordsite.pnl.gov/envreport. Report copies are also available at libraries in communities near the Hanford Site, at several university libraries in Washington and Oregon, and at the DOE's Public Reading Room located at the Consolidated Information Center in Richland, Washington. All versions of the report can be obtained from R. W. (Bill) Hanf, Pacific Northwest National Laboratory, P.O. Box 999, MS Richland, Washington, 99352 (bill.hanf@pnl.gov) while supplies last. Summary R. W. HanfEach year, the U.S. Department of Energy (DOE) publishes this integrated environmental report about the Hanford Site. Individual sections of the report are designed to:• Describe the Hanford Site and its mission• Summarize the Hanford Site's compliance with all applicable laws and regulations• Discuss the status and results of Hanford Site cleanup and remediation activities• Describe the environmental and groundwater...

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Testicular Atrophy in a Mule Deer Population

Cited by 17 publications

References 7 publications

Viruses in the Mammalian Male Genital Tract and Their Effects on the Reproductive System

Viruses in the Mammalian Male Genital Tract and Their Effects on the Reproductive System

Testis and Antler Dysgenesis in Sitka Black-Tailed Deer on Kodiak Island, Alaska: Sequela of Environmental Endocrine Disruption?

Hanford Site Environmental Report for Calender Year 2006

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