Testicular Biopsy in Evaluation of Male Infertility

Meinhard, E; McRae, C. U.; Chisholm, G. D.

doi:10.1136/bmj.3.5880.577

Cited by 53 publications

(23 citation statements)

References 4 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Jamal and Mansoor reported normal spermatogeneres in 15% cases [4] . Some studies showed a very low incidence of normal spermatogenesis as that by Meinhard et al who reported 5% [5] . 35% cases of normal spermatogenesis was reported by AlRayees et al [6] and Thomas J [7] .…”

Section: Discussionmentioning

confidence: 98%

Testicular Biopsy in Male Infertility

Ammal¹

2017

jmscr

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 98%

Testicular Biopsy in Male Infertility

Ammal¹

2017

jmscr

View full text Add to dashboard Cite

“…Alterations in testicular histology caused by poor fixation and processing may lead to misinterpretation of its structural integrity (Fig. 3) [8] and including "lumen blockage" in human testicular biopsies [ 7 ] . Therefore, the degeneration reported by others [4] could be the result of damage induced by processing and paraffin sectioning.…”

Section: Discussionmentioning

confidence: 99%

Effects of Stress on the Reproductive System of Male Rats and Mice

McGrady¹,

Chakraborty²

1983

Archives of Andrology

View full text Add to dashboard Cite

Male rats were immobilized for 2 hr/day, 5 days a week, for varying periods of time (7-3 I days) to assess the effects of stress on the reproductive system. Mice were immobilized for 25-38 days. The effectiveness of the stress was demonstrated by assessing the adrenal and body weight. Adrenal weights were significantly increased (p<.OS--t-test) compared to controls. Body weights were decreased compared to controls. No consistent change was noticed in the testicular weight and progressive motility of the spermatozoa drawn from the cauda epididymis and vas deferens. There were no deleterious effects of immobilization stress on the morphology of the differentiating germ cells, peritubular wall, and the interstitial tissues of the testis.

show abstract

“…Different dosages and durations of clomiphene therapy have been tried with oligospermic males and although a number of them do show some improvement, others show no change and some showed depression of sperm counts Swyer, 1972;Meinhard et a[., 1973;Halim et al, 1973). In a series of twelve normal men clomiphene therapy over 8 weeks induced a fall in the sperm count in four of the men (Jungck et al, 1964).…”

Section: Antioestrogens and Male Fertilitymentioning

confidence: 99%

Antioestrogens: A Review

Lunan¹,

Klopper²

1975

Clinical Endocrinology

View full text Add to dashboard Cite

Antioestrogens are a group of compounds which are at present attracting much attention both in scientific research and in clinical practice. The purpose of this article is to review the current understanding in both fields.Definitions of an antioestrogen. In the broadest sense, an antioestrogen is a substance which counteracts the activity of oestrogens (Terenius, 1974). For the purpose of this review, however, the definition will be restricted by the following considerations.(a) Direct eflect on oestrogen activity. Some substances do not counteract oestrogens directly but block subsequent events set in train by oestrogens. Hence substances which alter oestrogen response by interfering with protein or RNA synthesis in a target cell or with oestrogen metabolism in, say, the liver are not considered as antioestrogens in the context of this article. Neither is a substance which suppresses oestrogen secretion considered as an antioestrogen. Certain substances like androgens and progestogens can modify rather than counteract oestrogen effects. These substances do not interfere with oestrogen uptake by a target cell but modify the oestrogen response by stimulating other cell components (Terenius & Ljungkvist, 1972).(b) Blocking of oestrogen receptors. Antioestrogens have an affinity for the protein oestrogen-receptors in the target cell cytoplasm. Terenius (1970) has divided antioestrogens into two categories depending on the duration of receptor retention. The first group of antioestrogens is effective following systemic administration and has a sustained effect in blocking oestrogen stimulation : the second group is most effective when given locally, appears to be only transiently attached to the receptor but impedes the response to other oestrogens like oestradiol-17P (see Table 1).The scope of the review 1. Which oestrogen is blocked? Our interest is mainly in oestradiol-17P and to a lesser extent in oestradiol-17% and oestrone as these are the main gonadal oestrogens of the species

show abstract

Testicular Biopsy in Evaluation of Male Infertility

Cited by 53 publications

References 4 publications

Testicular Biopsy in Male Infertility

Testicular Biopsy in Male Infertility

Effects of Stress on the Reproductive System of Male Rats and Mice

Antioestrogens: A Review

Contact Info

Product

Resources

About