Testicular cancer patients undergoing cisplatin based chemotherapy exhibit temporary olfactory threshold scores changes

Walliczek‐Dworschak, Ute; Gudziol, Volker; Mitzschke, Claudia; Froehner, Michael; Hummel, Thomas

doi:10.1007/s00405-017-4559-y

Cited by 9 publications

(7 citation statements)

References 27 publications

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“… 93 Diminished olfactory sensitivity has also been reported in patients undergoing chemotherapy treatment. 94 Changes induced by chemotherapy treatment are often transitory and recover within six months post-treatment. 93 , 94 Alterations in chemosensory function in cancer patients undergoing chemotherapy can impact food preferences and practical and social aspects of everyday life.…”

Section: Chemosensory Abnormalities Associated With Chronic Diseasesmentioning

confidence: 99%

“… 94 Changes induced by chemotherapy treatment are often transitory and recover within six months post-treatment. 93 , 94 Alterations in chemosensory function in cancer patients undergoing chemotherapy can impact food preferences and practical and social aspects of everyday life. 95 Practitioners are advised to inform patients of potential alterations to their taste and smell perception prior to chemotherapy treatment.…”

Section: Chemosensory Abnormalities Associated With Chronic Diseasesmentioning

confidence: 99%

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Nutrition and taste and smell dysfunction

Kershaw

Mattes

2018

World j. otorhinolaryngol.-head neck surg.

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Food selection plays a pivotal role in maintaining adequate nutrient intake, thus elucidating drivers of food choice is a meaningful strategy to maintain health and manage disease. Taste and smell are key determinants of food choice and warrant careful consideration. In this review, we first discuss how sensory stimulation influences food selection and metabolism. We then review the evidence regarding the relationship between taste and smell dysfunction and food preferences and selection, with attention given to contexts of certain chronic diseases. We conclude with brief recommendations for the management of chemosensory disorders. While sensory abilities influence food selection, the effect of taste and smell dysfunction on long-term consumption patterns and health status must be considered in light of environment, exposure, and culture.

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Section: Chemosensory Abnormalities Associated With Chronic Diseasesmentioning

confidence: 99%

Section: Chemosensory Abnormalities Associated With Chronic Diseasesmentioning

confidence: 99%

Nutrition and taste and smell dysfunction

Kershaw

Mattes

2018

World j. otorhinolaryngol.-head neck surg.

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“…The control procedures in the threshold experiment were designed to minimize olfactory cues for control mice as well as CYP-treated mice. In addition, olfaction may not play a salient role for CYP-treated mice ashuman and murine data suggest that there are also disruptions to olfaction during and after chemotherapy treatment (Joseph et al 2017;Walliczek-Dworschak et al 2017). CYP groups in both experiments may have also experienced xerostomia, a side effect of chemotherapy that has been shown to affect gustatory sensitivity (Pico et al 1998;Temmel et al 2005).…”

Section: Discussionmentioning

confidence: 99%

Cyclophosphamide-Induced Disruptions to Appetitive Qualities and Detection Thresholds of NaCl: Comparison of Single-Dose and Dose Fractionation Effects

et al. 2018

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Chemotherapy is one of the most common treatments for cancer; however, a side effect is often altered taste. This study examined how cyclophosphamide, a chemotherapy drug, affects salt taste in mice. On the basis of previous findings, it was predicted that cyclophosphamide-induced disruptions in salt taste would be observed near days 2-4, 8-12, and 22-24 posttreatment, and that multiple, smaller doses would cause more severe disruptions to taste. To test these predictions, two experiments were performed, one using brief access testing to measure appetitive qualities, and another using operant conditioning to measure detection thresholds. After a single 100 mg/kg cyclophosphamide injection, peak alterations in brief access lick rates were seen near days 5-8 and 15 posttreatment, whereas peak alterations in detection thresholds were seen days 6, 14, and 20 posttreatment. After five 20 mg/kg injections of cyclophosphamide, brief access lick rates revealed disruptions only on postinjection day 8 whereas thresholds appeared to cycle, gradually increased to and decreased from peak elevations on posttreatment days 4, 10, 15, 20, and 23. Although salt taste functions were disrupted by cyclophosphamide, the patterns of these disruptions were less severe and shorter than expected from cell morphology studies, suggesting a functional adjustment to maintain behavioral accuracy. Fractionation of cyclophosphamide dosing had minimum effect on brief access responses but caused longer, cyclic-like disruptions of detection thresholds compared to single-dose administration.

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“…In a longitudinal study, Ijpma et al [24] showed decreased olfactory and gustatory sensitivities especially for salty taste in a group of 21 testicular cancer patients at their fourth cycle of cisplatin chemotherapy. Wallizcek-Dworschak et al [15] explored the influence of cisplatin on olfactory function and showed a significant decrease of olfactory threshold in a small group of 17 testicular cancer patients on day 90 of chemotherapy. In a longitudinal preliminary case-control study, Joussain et al [40] showed a decrease in the pleasantness and familiarity ratings of food odors in patients compared to controls after 2 cycles of chemotherapy.…”

Section: Discussionmentioning

confidence: 99%